Cladribine Enhances Apoptotic Cell Death in Lung Carcinoma Cells Over-Expressing DNase γ
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概要
- 論文の詳細を見る
Worldwide, lung cancer is the most common form of cancer and often has a poor prognosis. Establishment of effective therapies for lung cancer is a major concern in clinical cancer research. We compared the cytotoxic effects of chemotherapeutic agents including cisplatin, 5-fluorouracil, vinorelbine and cladribine, on a human lung cancer cell line, A549, and its derivative transfected with the DNase γ gene. We observed selective cytotoxicity of cladribine on the DNase γ-expressing sub-cell line of A549. Cladribine induces selective apoptosis in DNase γ-expressing A549 cells, which depends on activation of caspases. These results suggest that a combination therapy that includes cladribine along with the introduction of DNase γ has potential as a new therapeutic strategy for lung cancer.
- 公益社団法人 日本薬学会の論文
著者
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Magae Junji
Radiation Safety Research Center, Central Institute of Electric Power Industry
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Tanuma Sei-ichi
Department of Biochemistry, Tokyo University of Science
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Magae Junji
Radiation Safety Research Center Central Institute Of Electric Power Industry
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SUZUKI Haruhiko
Department of Immunology, Nagoya University Graduate School of Medicine
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Kamei Yuzuru
Department of Plastic and Reconstructive Surgery, Nagoya University Graduate School of Medicine
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Tanuma Sei-ichi
Department Of Biochemistry Faculty Of Pharmaceutical Science Science University Of Tokyo
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Hayakawa Akemi
Faculty of Science and Engineering, Tokyo University of Science
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Kamei Yuzuru
Department Of Plastic And Reconstruction Surgery Nagoya University Graduate School Of Medicine
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Suzuki Haruhiko
Department Of Electrical Engineering Fukushima National College Of Technology
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Tanuma Sei-ichi
Department of Biochemistry, Faculty of Pharmacy, Tokyo University of Science
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Magae Junji
Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry
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Suzuki Haruhiko
Department of Immunology, Graduate School of Medicine, Nagoya University
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