Elimination of Cell-cycle Regulators during Caspase-3-dependent Apoptosis Caused by an Immunosuppressant, FTY720(Biochemistry & Molecular Biology)

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概要

• 論文の詳細を見る

• The immunosuppressant, FTY720 causes apoptosis of lymphocytes, reduces numbers of lymphocytes in peripheral blood, and prevents infiltration of lymphocytes into allografts, which may be one of the mechanisms involved in its effects. Here we compared caspase activation and expression of cell-cycle regulators during apoptosis caused by FTY720, and Fas-stimulation in a mouse lymphoma transfected with human Fas antigen. FTY720 activated caspases-3, -8, and -9 as rapidly as did Fas-mediated apoptosis. The activation was blocked by a peptide inhibitor for caspase-3, DEVD-CHO. Fasinduced activation of caspases-8 and -9 was unaffected by the inhibitor. FTY720 eliminated proliferating cell nuclear antigen, retinoblastoma family members, differentiation regulated transcription factor polypetide-1, and cyclin H. These cell-cycle regulators were not eliminated when the peptide inhibitor was used. Dysfunction of cell-cycle regulators may play a critical role in the signal transduction pathway for activation of FTY720-mediated apoptosis.

• 社団法人日本農芸化学会の論文
• 2003-03-23

著者

• Magae Junji

  Radiation Safety Research Center, Central Institute of Electric Power Industry

• MAGAE Junji

  Department of Bioengineering, Tokyo Institute of Technology

• Magae J

  Tokyo Inst. Technol. Yokohama Jpn

• Magae Junji

  京都府立医科大学 麻酔学

• Magae Junji

  Dep. Of Biotechnology Inst. Of Res. And Innovation

• Magae Junji

  Radiation Safety Research Center Central Institute Of Electric Power Industry

• Magae J

  Inst. Res. And Innovation Kashiwa Jpn

• Nakajima Hiroo

  京都府立医科大学 内分泌･乳腺外科学部門

• Nakajima Hiroo

  Tsujigiwa Daigo Clinic 1-19 Daigo Shinmachi-uramachi Fushimi-ku Kyoto 601-1326 Jpn

• TSURUGA Mie

  Department of Biotechnology, Institute of Research and Innovation (IRI)

• LEE Yun-Sik

  National Institute of Bioscience and Human Technology

• NAKAJIMA Hiroo

  Laboratory of Breast Surgery, Department of Endocrine, Kyoto Prefectural University of Medicine

• Nakajima H

  Department Of Endocrine Breast Surgery Kyoto Prefectural University Of Medicine

• Tsuruga Mie

  Department Of Biotechnology Institute Of Research And Innovation (iri)

• Nakajima Hidenori

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd

• Tsuruga Mie

  Department Of Biotechnology Institute Of Research And Innovation

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