Action of FR901228, a Novel Antitumor Bicyclic Depsipeptide Produced by Chromobacterium violaceum No. 968, on Ha-ras Transformed NIH3T3 Cells

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概要

• 論文の詳細を見る

• FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and inhibited their growth. The reduction of c-myc expression was observed in FR901228-treated Ras-1 cells by RNA dot-blot hybridization. This reduction of c-myc expression and morphological reversion of the transformed cells to normal were correlated with growth inhibition (G_0/G_1 arrest in cell cycle).

• 社団法人日本農芸化学会の論文
• 1994-09-23

著者

• Nakajima Hiroo

  京都府立医科大学 内分泌･乳腺外科学部門

• Nakajima Hiroo

  Tsujigiwa Daigo Clinic 1-19 Daigo Shinmachi-uramachi Fushimi-ku Kyoto 601-1326 Jpn

• OKUHARA Masakuni

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• UEDA HIROTSUGU

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• HORI Yasuhiro

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Nakajima H

  Department Of Endocrine Breast Surgery Kyoto Prefectural University Of Medicine

• NAKAJIMA Hidenori

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Goto Toshio

  ,Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Hori Yasuhiro

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hori Y

  Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O

• Hori Yasuhiro

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Ueda Horotsugu

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Ueda Hirotsugu

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Ueda H

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Okuhara M

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Okuhara Masakuni

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Nakajima Hidenori

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd

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