A New Antimitotic Substance, FR182877 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
スポンサーリンク
概要
- 論文の詳細を見る
- 2000-02-25
著者
-
佐藤 文治
藤沢薬品探研
-
SATO BUNJI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
HINO MOTOHIRO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
TAKASE SHIGEHIRO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
HORI Yasuhiro
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
HASHIMOTO Seiji
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
TERANO Hiroshi
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd
-
Shibata T
Research Planning Research Division Fujisawa Pharmaceutical Co. Ltd.
-
Hashimoto Michizane
Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.
-
Hashimoto Michizane
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Sato Bunji
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Hino Motohiro
Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Hori Yasuhiro
Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Hori Yasuhiro
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Terano Hiroshi
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
MIYAUCHI Michiyo
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
Takase S
Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.
-
Hashimoto Seiji
Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Hashimoto Seiji
Department Of Nephrology Division Sapporo General City Hospital
-
佐藤 文治
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
MURAMATSU Hedeyuki
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
Miyauchi Michiyo
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Hino Motohiro
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Hino Motohiro
Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.
-
Takase Shigehiro
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Hashimoto Seiji
Department Of Biotechnology Toyama Prefectural University
-
Muramatsu Hedeyuki
Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.
-
Hashimoto Seiji
Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
関連論文
- 1P039 抗生物質代謝酵素の基質結合シミュレーション(蛋白質-構造機能相関,第48回日本生物物理学会年会)
- The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No. 19353 : II. Biological Profiles
- Naphthalecin, a Novel Antibiotic Produced by the Anaerobic Bacterium, Sporotalea colonica sp. nov.
- 83(P69) 新規微小管作用物質WS9885B(ポスター発表の部)
- カイコガ脳内ペプチド, bombyxin類の化学構造(有機化学・天然物化学-生理活性物質(昆虫)-)
- FR901464の転写調節活性および抗腫瘍作用 : 微生物
- FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919 : II. Biological Profiles
- FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919 : I. Taxonomy of the Producing Organism, Fermentation, Islation and Physico-chemical Properties
- FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604 : II. Biological Activities
- FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties
- The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No.19353 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
- FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase (HDAC) II. Biological Activities in Animal Models
- FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No.408813 III. In Vivo Activities
- FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase (HDAC) I. Taxonomy, Fermentation, Isolation and Biological Activities
- FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No.408813 II. In Vitro Property and Mode of Action
- FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No.11243 : II. In Vitro and In Vivo Activities
- Steroid-sensitive nephrotic syndrome associated with positive C1q immunofluorescence
- Unilateral renal cortical necrosis with contralateral hydronephrosis after surgery for uterus carcinoma
- FR227673 and FR190293, Novel Antifungal Lipopeptides from Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616
- FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 : I. Taxonomy, Fermentation, and Biological Properties
- FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No. 002 : II. Biological Properties and Model of Action
- Inhibition of Growth and Metastasis of Ovarian Carcinoma by Administering a Drug Capable of Interfering with Vascular Endothelial Growth Factor Activity
- カイコ羽化ホルモン遺伝子のクローニング(有機化学・天然物化学-生理活性物質(昆虫)-)
- FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase III. Structure Determination
- A New Antimitotic Substance, FR182877 : II. The Mechanism of Action
- New Antitumor Substances, FR901463, FR901464 and FR901465 III. Structures of FR901463, FR901464 and FR901465
- New Antitumor Substances, FR901463, FR901464 and FR901465 II. Activities against Experimental Tumors in Mice and Mechanism of Action
- New Antitumor Substances, FR901464 and FR901465 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
- Action of FR901228, a Novel Antitumor Bicyclic Depsipeptide Produced by Chromobacterium violaceum No. 968, on Ha-ras Transformed NIH3T3 Cells
- Site-specific Structural Transformation of the Novel Antifungal Cyclic Depsipeptide FR901469 : Synthesis and Biological Activity of FR203904
- FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573
- FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738 : II. In Vitro and In Vivo Antifungal Activity
- FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No. 002 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
- FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No. 11243 : III. Structure Determination
- FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No.11243 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties
- FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
- FR198248, a New Anti-influenza Agent isolated from Aspergillus terreus No.13830 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
- A New Assay Method for Immunosuppressants with a Tacrolimus (FK506)-Like Mode of Action
- The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : III. Structure Determination
- FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 : II. Isolation and Structure Elucidation
- A New Antimitotic Substance, FR182877 : III. Structure Determination
- Oxidative Activities of Heterologously Expressed CYP107B1 and CYP105D1 in Whole-Cell Biotransformation Using Streptomyces lividans TK24(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : II. Biological Activities
- The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
- FR182876, a New Microtubule Modulator with High Water-solubility, from a Streptomyces
- The Novel Gluconeogenesis Inhibitors FR225659 and FR225656 from Helicomyces sp. No. 19353 : III. Structure Determination
- FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No.408813 I. Taxonomy, Ferimentation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523
- New Anti-influenza Agents, FR198248 and Its Derivatives : II. Characterization of FR198248, Its Related Compounds and Some Derivatives
- FR191512 , a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415 : II. Biological Properties
- FR191512 , a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation
- WA8242A_1, A_1 and B, Novel Secretory Phospholipase A_1 Inhibitors Produced by Streptomyces violaceusniger I. Taxonomy, Production and Purification
- FR225659-binding Proteins : Identification as Serine/Threonine Protein Phosphatase PP1 and PP2A Using High-performance Affinity Beads
- A Comparative Study of Malaysian and Japanese Actinomycetes Using a Simple Identification Method Based on Partial 16S rDNA Sequence
- A New Antimitotic Substance, FR182877 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
- Pulmonary Hyalinizing Granuloma with Hydronephrosis
- WF14865A and B, New Cathepsins B and L Inhibitors Produced by Aphanoascus fulvescens I. Taxonomy, Production, Purification and Biological Properties
- WF14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp. I. Taxonomy, Production Purification and Structure Elucidation
- Siderophore Production and Induction of Iron-regulated Proteins by a Microorganism from Rhizosphere of Barley(Microbiology & Fermentation Technology)
- WS75624 A and B, New Endothelin Converting Enzyme Inhibitors Isolated from Saccharothrix sp.No.75624 I.Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
- WF14861, a New Cathepsins B and L Inhibitor Produced by Collectotrichum sp. II. Biological Properties
- WA8242A_1, A_2 and B, Novel Secretary Phospholipase A_2 Inhibitors Produced by streptomyces violaceusinger III. Structure Elucidation and Total Synthesis of WA8242B
- WA8242A_1, A_2 and B, Novel Secrtory Phospholipase A_2 Inhibitors Produced by Streptomyces violaceusniger II. Biological Properties
- Identification of Flexible Structures : a Gray Box Approach
- DVFC-Based Identification and Its Application to Robust Vibration Suppression Control of Flexible Structures
- A New Aromatase Inhibitor, FR901537 I.Taxonomy, Fermentation, Isolation, Physicochemical Characteristics
- WS75624 A and B, New Endothelin Converting Enzyme Inhibitors Isolated from Saccharothrix sp.No.75624 II.Structure Elucidation of WS75624 A and B
- Bubble Splitting by Turbulent Jet Emitted from Orifice
- Strain selection and scale-up fermentation for FR901379 acylase production by Streptomyces sp. no. 6907(METHOD)
- Cloning and expression of the FR901379 acylase gene from Streptomyces sd. no. 6907
- Anti-herpes virus activity of polyether antibiotic CP-44161 in vivo
- Discovery of anti-varicella zoster virus activity of polyether antibiotic CP-44161
- Screening and characterization of microorganisms with FR901379 acylase activity
- AS1387392, a novel immunosuppressive cyclic tetrapeptide compound with inhibitory activity against mammalian histone deacetylase
- Cloning and heterologous expression of P450Um-1, a novel bacterial P450 gene, for hydroxylation of immunosuppressive agent AS1387392
- Bioconversion of AS1387392 : bioconversion studies involving Amycolatopsis azurea JCM 3275
- Bioconversion of AS1387392 : screening and characterization of actinomycetes that convert AS1387392 to AS1429716
- A case of adefovir-induced membranous nephropathy related to hepatitis B caused by lamivudine-resistant virus after liver transplant due to Byler's disease
- Sapphirine from Metamorphosed Layered Complex of Mt. Poroshiri, Hidaka Metamorphic Belt, Hokkaido