WA8242A_1, A_1 and B, Novel Secretory Phospholipase A_1 Inhibitors Produced by Streptomyces violaceusniger I. Taxonomy, Production and Purification

スポンサーリンク

概要

• 論文の詳細を見る
• 1998-01-25

著者

• OKUHARA Masakuni

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• HATANAKA Hiroshi

  Division of Protein Biosynthesis, Institute for Protein Research, Osaka University

• TSURUMI YASUHISA

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• YOSHIMURA SEIJI

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd

• HASHIMOTO Seiji

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Hatanaka H

  Fujisawa Pharmaceutical Co. Ltd. Aichi Jpn

• TSURUMI Yasuhisa

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Hatanaka Hiroshi

  Division Of Protein Biosynthesis Institute For Protein Research Osaka University

• Hatanaka Hiroshi

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Otsuka Takanao

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• YOSHIMURA Seiji

  Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Yoshimura S

  Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hatori H

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• MURAMATSU Yuko

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• OKAMOTO Masanori

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Muramatsu Yuko

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Okuhara M

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Okuhara Masakuni

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Tsurumi Yasuhisa

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Okudaira Terumi

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hashimoto Seiji

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

関連論文

• 1P039 抗生物質代謝酵素の基質結合シミュレーション(蛋白質-構造機能相関,第48回日本生物物理学会年会)
• Tachykinin Antagonists Screening from Microbial Origin
• Regulation of Reactive Oxygen Species by Nerve Growth Factor but not Bcl-2 as a Novel Mechanism of Protection of PC12 Cells from Superoxide Anion-Induced Death
• Free Radical-Independent Protection by Nerve Growth Factor and Bcl-2 of PC12 Cells from Hydrogen Peroxide-Triggered Apoptosis
• Repair of Chromosomal Damage : Transcription-Coupled DNA Repair and Its Disorders(Symposium : Manipulating Chromosomes)(Abstracts of the 52nd Annual Meeting of the Society of Chromosome Research)
• FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919 : II. Biological Profiles
• FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919 : I. Taxonomy of the Producing Organism, Fermentation, Islation and Physico-chemical Properties
• FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604 : II. Biological Activities
• FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties
• The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No.19353 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
• FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase (HDAC) I. Taxonomy, Fermentation, Isolation and Biological Activities
• FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No.11243 : II. In Vitro and In Vivo Activities
• Steroid-sensitive nephrotic syndrome associated with positive C1q immunofluorescence
• Unilateral renal cortical necrosis with contralateral hydronephrosis after surgery for uterus carcinoma
• Analysis of Tyrosine Phosphorylation-Dependent Protein-Protein Interactions in TrkB-Mediated Intracellular Signaling Using Modified Yeast Two-Hybrid System^1
• Comparison of Survival-Promoting Effects of Brain-Derived Neurotrophic Factor and Neurotrophin-3 on PC12h Cells Stably Expressing TrkB Receptor^1
• MS-430, a Synthetic Pyrimidine Derivative, Influences the Intracellular Signal transduction Pathway Leading to Neuronal Differentiation of PC12h Cells
• FR227673 and FR190293, Novel Antifungal Lipopeptides from Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616
• FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase III. Structure Determination
• A New Antimitotic Substance, FR182877 : II. The Mechanism of Action
• New Antitumor Substances, FR901463, FR901464 and FR901465 II. Activities against Experimental Tumors in Mice and Mechanism of Action
• New Antitumor Substances, FR901464 and FR901465 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• Action of FR901228, a Novel Antitumor Bicyclic Depsipeptide Produced by Chromobacterium violaceum No. 968, on Ha-ras Transformed NIH3T3 Cells
• Site-specific Structural Transformation of the Novel Antifungal Cyclic Depsipeptide FR901469 : Synthesis and Biological Activity of FR203904
• FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573
• FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738 : II. In Vitro and In Vivo Antifungal Activity
• FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No. 11243 : III. Structure Determination
• FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No.11243 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties
• FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
• FR198248, a New Anti-influenza Agent isolated from Aspergillus terreus No.13830 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• FR901483, a Novel Immunosuppressant Isolated from Cladobotryum sp. No. 11231 Taxonomy of the Producing Organism, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• A New Assay Method for Immunosuppressants with a Tacrolimus (FK506)-Like Mode of Action
• Apoptosis-Signal Regulating Kinase-1 Is Involved in the Low Potassium-Induced Activation of p38 Mitogen-Activated Protein Kinase and c-Jun in Cultured Cerebellar Granule Neurons
• Brain-derived neurotrophic factor prevents superoxide anion-induced death of PC12h cells stably expressing TrkB receptor via modulation of reactive oxygen species
• The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : III. Structure Determination
• FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 : II. Isolation and Structure Elucidation
• A New Antimitotic Substance, FR182877 : III. Structure Determination
• The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
• FR182876, a New Microtubule Modulator with High Water-solubility, from a Streptomyces
• The Novel Gluconeogenesis Inhibitors FR225659 and FR225656 from Helicomyces sp. No. 19353 : III. Structure Determination
• Role of Neurotrophin in Low K^+-Mediated Apoptosis of Cultured Cerebellar Granule Neurons
• New Anti-influenza Agents, FR198248 and Its Derivatives : II. Characterization of FR198248, Its Related Compounds and Some Derivatives
• FR191512 , a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415 : II. Biological Properties
• FR191512 , a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation
• Irreversibility of Adiabatic Demagnetization in the Rotating Frame in Double and Single Quantum NMR in Solids
• WA8242A_1, A_1 and B, Novel Secretory Phospholipase A_1 Inhibitors Produced by Streptomyces violaceusniger I. Taxonomy, Production and Purification
• FR225659-binding Proteins : Identification as Serine/Threonine Protein Phosphatase PP1 and PP2A Using High-performance Affinity Beads
• A Comparative Study of Malaysian and Japanese Actinomycetes Using a Simple Identification Method Based on Partial 16S rDNA Sequence
• A New Antimitotic Substance, FR182877 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• WF14865A and B, New Cathepsins B and L Inhibitors Produced by Aphanoascus fulvescens I. Taxonomy, Production, Purification and Biological Properties
• WF14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp. I. Taxonomy, Production Purification and Structure Elucidation
• Isolation and Characterization of Mutants of Saccharomyces cerevisiae Resistant to Killer Toxin of Kluyveromyces lactis
• Plasma Cholesterol Reducing Effect of FR129169, a Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor, in the Rat
• WS75624 A and B, New Endothelin Converting Enzyme Inhibitors Isolated from Saccharothrix sp.No.75624 I.Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• WF14861, a New Cathepsins B and L Inhibitor Produced by Collectotrichum sp. II. Biological Properties
• WA8242A_1, A_2 and B, Novel Secretary Phospholipase A_2 Inhibitors Produced by streptomyces violaceusinger III. Structure Elucidation and Total Synthesis of WA8242B
• WA8242A_1, A_2 and B, Novel Secrtory Phospholipase A_2 Inhibitors Produced by Streptomyces violaceusniger II. Biological Properties
• Generation of Free Radicals during the Death of Saccharomyces cerevisiae Caused by Lipid Hydroperoxide
• Biological and Pharmacological Properties of Highly Selective New Endothelin Converting Enzyme Inhibitor WS79089B Isolated from Streptosporangium roseum No.79089
• Acceleration of Recovery from Mitomycin C-induced Leukopenia by FK-565
• DIKETOPIPERAZINE DERIVATIVES, A NEW SERIES OF PLATELET-ACTIVATING FACTOR INHIBITORS(Communications to the Editor)
• BDNF rapidly induces aspartate release from cultured CNS neurons
• WS75624 A and B, New Endothelin Converting Enzyme Inhibitors Isolated from Saccharothrix sp.No.75624 II.Structure Elucidation of WS75624 A and B
• Survival of and 1-methyl-4-phenylpyridinium (MPP^+) neurotoxicity against dopaminergic neurons in coculture of rat mesencephalon with their target of non-target regions
• Strain selection and scale-up fermentation for FR901379 acylase production by Streptomyces sp. no. 6907(METHOD)
• Cloning and expression of the FR901379 acylase gene from Streptomyces sd. no. 6907
• Screening and characterization of microorganisms with FR901379 acylase activity

もっと見る 閉じる

スポンサーリンク