FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 : II. Isolation and Structure Elucidation

スポンサーリンク

概要

• 論文の詳細を見る

• We discovered FR207944 produced by Chaetomium sp. No. 217 in the course of screening for antifungal antibiotics from natural products. FR207944 is identical with fuscoatroside, described in the preceding paper as an anti-Aspergillus flavus agent. Determination of the relative stereochemistry of fuscoatroside was made formally by comparison with WF11605 (16-Oxo-FR207944). We confirmed the stereochemistry on the basis of single crystal X-ray analysis.

• 社団法人 日本農芸化学会の論文
• 2005-05-23

著者

• Kinoshita T

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Kinoshita Takayoshi

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Fujie Akihiko

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• HASHIMOTO Michizane

  Fermentation Research Laboratories, Drug Discovery Research, Astellas Pharma Inc.

• TAKASE SHIGEHIRO

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• KOBAYASHI Motoo

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• HINO Motohiro

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• HASHIMOTO Seiji

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• HORI Yasuhiro

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Takase Shigehiro

  Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.

• Shibata T

  Research Planning Research Division Fujisawa Pharmaceutical Co. Ltd.

• Hashimoto Michizane

  Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.

• Hashimoto Michizane

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hino Motohiro

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Fujie Akihiko

  Fermentation Research Laboratories Astellas Pharma Inc.

• Hori Yasuhiro

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• YOSHIMURA Seiji

  Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Kinoshita Takayoshi

  Exploratory Research Laboratoeis Fujisawa Pharmaceutical Co. Ltd.

• Takase S

  Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.

• Hashimoto Seiji

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hashimoto Seiji

  Department Of Nephrology Division Sapporo General City Hospital

• Yoshimura S

  Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Kobayashi Motoo

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Fujie Akihiko

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hino Motohiro

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hino Motohiro

  Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.

• Takase Shigehiro

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hashimoto Seiji

  Department Of Biotechnology Toyama Prefectural University

• Hino Motohiro

  Fermentation And Biotechnology Laboratories Astellas Pharma Inc.

• Hashimoto Michizane

  Fermentation And Biotechnology Laboratories

• Hashimoto Seiji

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

関連論文

• Protein Crystallization by Combining Laser Irradiation and Solution-Stirring Techniques
• 1P039 抗生物質代謝酵素の基質結合シミュレーション(蛋白質-構造機能相関,第48回日本生物物理学会年会)
• The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No. 19353 : II. Biological Profiles
• Control of Protein Crystal Nucleation and Growth Using Stirring Solution
• Generation of Protein Crystals Using a Solution-Stirring Technique
• Improving the Quality of Protein Crystals Using Stirring Crystallization
• Naphthalecin, a Novel Antibiotic Produced by the Anaerobic Bacterium, Sporotalea colonica sp. nov.
• FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919 : II. Biological Profiles
• FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919 : I. Taxonomy of the Producing Organism, Fermentation, Islation and Physico-chemical Properties
• FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604 : II. Biological Activities
• FR171456, a Novel Cholesterol Synthesis Inhibitor Produced by Sporormiella minima No. 15604 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties
• The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No.19353 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
• FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase (HDAC) II. Biological Activities in Animal Models
• FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No.408813 III. In Vivo Activities
• FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase (HDAC) I. Taxonomy, Fermentation, Isolation and Biological Activities
• FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No.408813 II. In Vitro Property and Mode of Action
• FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No.11243 : II. In Vitro and In Vivo Activities
• Steroid-sensitive nephrotic syndrome associated with positive C1q immunofluorescence
• Unilateral renal cortical necrosis with contralateral hydronephrosis after surgery for uterus carcinoma
• FR227673 and FR190293, Novel Antifungal Lipopeptides from Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616
• FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 : I. Taxonomy, Fermentation, and Biological Properties
• FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No. 002 : II. Biological Properties and Model of Action
• FR235222, a Fungal Metabolite, is a Novel Immunosuppressant that Inhibits Mammalian Histone Deacetylase III. Structure Determination
• A New Antimitotic Substance, FR182877 : II. The Mechanism of Action
• New Antitumor Substances, FR901463, FR901464 and FR901465 III. Structures of FR901463, FR901464 and FR901465
• New Antitumor Substances, FR901463, FR901464 and FR901465 II. Activities against Experimental Tumors in Mice and Mechanism of Action
• New Antitumor Substances, FR901464 and FR901465 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• Action of FR901228, a Novel Antitumor Bicyclic Depsipeptide Produced by Chromobacterium violaceum No. 968, on Ha-ras Transformed NIH3T3 Cells
• Site-specific Structural Transformation of the Novel Antifungal Cyclic Depsipeptide FR901469 : Synthesis and Biological Activity of FR203904
• FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573
• FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738 : II. In Vitro and In Vivo Antifungal Activity
• FR227244, a Novel Antifungal Antibiotic from Myrothecium cinctum No. 002 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
• FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No. 11243 : III. Structure Determination
• FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No.11243 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties
• FR209602 and Related Compounds, Novel Antifungal Lipopeptides from Coleophoma crateriformis No. 738 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
• FR198248, a New Anti-influenza Agent isolated from Aspergillus terreus No.13830 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• FR901483, a Novel Immunosuppressant Isolated from Cladobotryum sp. No. 11231 Taxonomy of the Producing Organism, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• The First Example for Cycloenantiomeric Hexahomooxacalix[3]arenes
• The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : III. Structure Determination
• FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 : II. Isolation and Structure Elucidation
• A New Antimitotic Substance, FR182877 : III. Structure Determination
• Oxidative Activities of Heterologously Expressed CYP107B1 and CYP105D1 in Whole-Cell Biotransformation Using Streptomyces lividans TK24(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
• The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : II. Biological Activities
• The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
• FR182876, a New Microtubule Modulator with High Water-solubility, from a Streptomyces
• The Novel Gluconeogenesis Inhibitors FR225659 and FR225656 from Helicomyces sp. No. 19353 : III. Structure Determination
• FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No.408813 I. Taxonomy, Ferimentation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523
• New Anti-influenza Agents, FR198248 and Its Derivatives : II. Characterization of FR198248, Its Related Compounds and Some Derivatives
• FR191512 , a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415 : II. Biological Properties
• FR191512 , a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation
• WA8242A_1, A_1 and B, Novel Secretory Phospholipase A_1 Inhibitors Produced by Streptomyces violaceusniger I. Taxonomy, Production and Purification
• FR225659-binding Proteins : Identification as Serine/Threonine Protein Phosphatase PP1 and PP2A Using High-performance Affinity Beads
• A Comparative Study of Malaysian and Japanese Actinomycetes Using a Simple Identification Method Based on Partial 16S rDNA Sequence
• A New Antimitotic Substance, FR182877 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• Pulmonary Hyalinizing Granuloma with Hydronephrosis
• WF14865A and B, New Cathepsins B and L Inhibitors Produced by Aphanoascus fulvescens I. Taxonomy, Production, Purification and Biological Properties
• WF14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp. I. Taxonomy, Production Purification and Structure Elucidation
• Siderophore Production and Induction of Iron-regulated Proteins by a Microorganism from Rhizosphere of Barley(Microbiology & Fermentation Technology)
• WS75624 A and B, New Endothelin Converting Enzyme Inhibitors Isolated from Saccharothrix sp.No.75624 I.Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• WF14861, a New Cathepsins B and L Inhibitor Produced by Collectotrichum sp. II. Biological Properties
• WA8242A_1, A_2 and B, Novel Secretary Phospholipase A_2 Inhibitors Produced by streptomyces violaceusinger III. Structure Elucidation and Total Synthesis of WA8242B
• WA8242A_1, A_2 and B, Novel Secrtory Phospholipase A_2 Inhibitors Produced by Streptomyces violaceusniger II. Biological Properties
• Identification of Flexible Structures : a Gray Box Approach
• DVFC-Based Identification and Its Application to Robust Vibration Suppression Control of Flexible Structures
• A New Aromatase Inhibitor, FR901537 I.Taxonomy, Fermentation, Isolation, Physicochemical Characteristics
• WS75624 A and B, New Endothelin Converting Enzyme Inhibitors Isolated from Saccharothrix sp.No.75624 II.Structure Elucidation of WS75624 A and B
• Bubble Splitting by Turbulent Jet Emitted from Orifice
• ILVIII-7 Discovery of Micafungin (FK463) : a Novel antifungal drug from Natural Products(Drug Discovery and Developments)
• Strain selection and scale-up fermentation for FR901379 acylase production by Streptomyces sp. no. 6907(METHOD)
• Cloning and expression of the FR901379 acylase gene from Streptomyces sd. no. 6907
• Anti-herpes virus activity of polyether antibiotic CP-44161 in vivo
• Discovery of anti-varicella zoster virus activity of polyether antibiotic CP-44161
• Screening and characterization of microorganisms with FR901379 acylase activity
• AS1387392, a novel immunosuppressive cyclic tetrapeptide compound with inhibitory activity against mammalian histone deacetylase
• Cloning and heterologous expression of P450Um-1, a novel bacterial P450 gene, for hydroxylation of immunosuppressive agent AS1387392
• Bioconversion of AS1387392 : bioconversion studies involving Amycolatopsis azurea JCM 3275
• Bioconversion of AS1387392 : screening and characterization of actinomycetes that convert AS1387392 to AS1429716
• Protein Crystallization by Combining Laser Irradiation and Solution-Stirring Techniques
• A case of adefovir-induced membranous nephropathy related to hepatitis B caused by lamivudine-resistant virus after liver transplant due to Byler's disease
• Generation of Protein Crystals Using a Solution-Stirring Technique
• Improving the Quality of Protein Crystals Using Stirring Crystallization
• Sapphirine from Metamorphosed Layered Complex of Mt. Poroshiri, Hidaka Metamorphic Belt, Hokkaido
• Enhanced oxidative activities of cytochrome P450Rhf from Rhodococcus sp. expressed using the hyper-inducible expression system(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

もっと見る 閉じる

スポンサーリンク