FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 : I. Taxonomy, Fermentation, and Biological Properties

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概要

• 論文の詳細を見る

• An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against Aspergillus fumigatus and Candida albicans. Specifically, FR207944 exhibits in vitro and in vivo antifungal activity against A. fumigatus. The effects of FR207944 on the morphology of A. fumigatus were shown to be similar to those of FR901379, a known 1,3-β-glucan synthase inhibitor. The MECs of FR207944 against A. fumigatus FP1305 and C. albicans FP633 in micro-broth dilution test were 0.039 and 1.6 μg/ml respectively. FR207944 showed good potency by subcutaneous injection and oral administration against A. fumigatus in a murine systemic infection model, with ED50s of 5.7 and 17 mg/kg respectively.

• 社団法人 日本農芸化学会の論文
• 2005-03-23

著者

• Sakamoto Kazutoshi

  Fermentation Research Laboratories, Astellas Pharma Inc.

• Sato I

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Sato Ikuko

  藤沢薬品工業

• Sato Ikuko

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Fujie Akihiko

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• EZAKI Masami

  Fermentation Research Laboratories, Drug Discovery Research, Astellas Pharma Inc.

• HASHIMOTO Michizane

  Fermentation Research Laboratories, Drug Discovery Research, Astellas Pharma Inc.

• Sakamoto K

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Sakamoto K

  Fujisawa Pharmaceutical Co. Ltd. Ibaraki Jpn

• Sakamoto Kazutoshi

  Fermentation Research Laboratories Astellas Pharma Inc.

• Sakamoto Kazutoshi

  National Research Institute Of Brewing

• KANASAKI Ryuichi

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• KOBAYASHI Motoo

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• HINO Motohiro

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• HORI Yasuhiro

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• ABE Fumie

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• NITTA Kumiko

  Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Hashimoto Michizane

  Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.

• Hashimoto Michizane

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Abe Fumie

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Nitta Kumiko

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Ezaki M

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Ezaki Masami

  Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.

• Hino Motohiro

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Fujie Akihiko

  Fermentation Research Laboratories Astellas Pharma Inc.

• Hori Yasuhiro

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Kanasaki Ryuichi

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Kobayashi Motoo

  Fermentation Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Fujie Akihiko

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hino Motohiro

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hino Motohiro

  Fermentation Research Laboratories Drug Discovery Research Astellas Pharma Inc.

• Hino Motohiro

  Fermentation And Biotechnology Laboratories Astellas Pharma Inc.

• Hashimoto Michizane

  Fermentation And Biotechnology Laboratories

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