Lack of endoplasmic reticulum 1,2-α-mannosidase activity that trims N-glycan Man_9GlcNAc_2 to Man_8GlcNAc_2 isomer B in a manE gene disruptant of Aspergillus oryzae(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
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概要
- 論文の詳細を見る
The gene manE, encoding a probable class I endoplasmic reticulum 1,2-α-mannosidases (ER-Man), was identified from the filamentous fungus Aspergillus oryzae due to similarity to orthologs. It removes a single mannose residue from Man_9GlcNAc_2, generating Man_8GlcNAc_2 isomer B. Disruption of manE caused drastic decreases in ER-Man activity in A. oryzae microsomes.
- 公益社団法人日本生物工学会の論文
著者
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Akao Takeshi
National Research Institute of Brewing
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Yamada Osamu
National Cardiovascular Center
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Sakamoto Kazutoshi
National Research Institute Of Brewing
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Akita O
Fac. Of Human Life Sciences Dep. Of Food And Health Sciences Jissen Women's Univ.
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Akita Osamu
National Research Institute Of Brewing
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Yamato Osamu
Kagoshima Univ. Kagoshima
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Akao T
National Research Institute Of Brewing
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Yahara Akinori
Hiroshima University Graduate School Of Advanced Sciences Of Matter
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Yamada O
Laboratory Of Clinical Pathology Department Of Veterinary Clinical Sciences Faculty Of Agriculture K
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Yoshida Takashi
Faculty Of Agriculture And Life Science Hirosaki University
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Yahara Akinori
National Research Institute of Brewing
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