Elevated Expression of Genes under the Control of Stress Response Element (STRE) and Msn2p in an Ethanol-Tolerance Sake Yeast Kyokai No. 11(BREWING AND FOOD TECHNOLOGY)
スポンサーリンク
概要
- 論文の詳細を見る
The sake yeast strain Kyokai no. 11 (K11) is an ethanol-tolerant mutant of strain Kyokai no. 7 (K7), which shows higher viability in an ethanol solution than strain K7. To clarify the mechanism underlying the ethanol tolerance of this strain, the gene expression profiles of K7 and K11 were analyzed using DNA microarrays. The results indicate that many genes induced by stresses were highly expressed in strain K11 not exposed to stresses. Analysis of HSP12, one of the most highly expressed genes in strain K11 compared with strain K7, revealed that a trans-acting factor of strain K11 was involved in the elevated expression of HSP12. Many of the highly expressed genes in strain K11 including HSP12 were under the control of a cis-acting factor called the stress response element (STRE). The addition of STRE sequences to a promoter region of a reporter gene resulted in constitutive high-level expression in strain K11. It was reported that transcription factors Msn2p and Msn4p bind to STRE sequences. DNA sequence analyses of MSN2 and MSN4 of strains K7 and K11 revealed that only Msn2p was functional in these strains. When two copies of MSN2 in strain K11 were disrupted, the expression level of the reporter gene under the control of STRE decreased to the level of strain K7, indicating that Msn2p is required for the elevated expression of the STRE-controlled genes in K11.
- 2007-09-25
著者
-
Watanabe Mamoru
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
-
Tamura Kenichi
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
-
Magbanua Jose
National Research Institute of Brewing
-
Takano Kaname
Department of Biotechnology, The University of Tokyo
-
Kitamoto Katsuhiko
Department of Biotechnology, The University of Tokyo
-
Kitagaki Hiroshi
National Research Institute of Brewing
-
Akao Takeshi
National Research Institute of Brewing
-
Shimoi Hitoshi
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
-
Kitamoto Katsuhiko
Department Of Biotechnology The University Of Tokyo
-
Shimoi H
Hiroshima Univ. Higashihiroshima Jpn
-
Shimoi H
Hiroshima Univ. Higashi‐hiroshima Jpn
-
Shimoi Hitoshi
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
-
Watanabe Mamoru
National Research Institute Of Brewing:graduate School Of Advanced Sciences Of Matter Hiroshima Univ
-
Watanabe Mamoru
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Tokyo Medical And Dental U
-
Takano Kaname
Department Of Biotechnology The University Of Tokyo
-
Tamura Kenichi
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
-
Kitamoto Katsuhiko
Department Of Applied Biological Chemistry And Department Of Applied Biological Engineering Graduate
-
Watanabe Mamoru
Department Of Biology Faculty Of Education Mie University
-
Tamura Kenichi
Department Of Electrical Engineering Tokyo Metropolitan University
-
Watanabe Mamoru
Department Of Applied Mathematics Okayama University Of Science
-
Kitamoto Katsuhiko
Dep. Of Biotechnology The Univ. Of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-8657 Jpn
-
TAMURA Kenichi
Department of Electrical and Electronic Engineering, Tokyo Metropolitan University
関連論文
- Elevated Expression of Genes under the Control of Stress Response Element (STRE) and Msn2p in an Ethanol-Tolerance Sake Yeast Kyokai No. 11(BREWING AND FOOD TECHNOLOGY)
- A Eukaryotic Copper-Containing Nitrite Reductase Derived from a NirK Homolog Gene of Aspergillus oryzae
- Cloning of Aspergillus oryzae Aovps5 gene, homologous to vacuolar protein sorting associated gene VPS5 and construction of the disruptant(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Disruption of ubiquitin-related genes in laboratory yeast strains enhances ethanol production during sake brewing(BREWING AND FOOD TECHNOLOGY)
- Overexpression of MSN2 in a sake yeast strain promotes ethanol tolerance and increases ethanol production in sake brewing(BREWING AND FOOD TECHNOLOGY)
- Systemically Circulating Colitogenic Memory CD4^+ T Cells May Be an Ideal Target for the Treatment of Inflammatory Bowel Diseases
- S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans II. Structure Elucidation
- Purification and Characterization of Termite Endogenous β-1,4-Endoglucanases Produced in Aspergillus oryzae
- Multidrug Resistance Phenotype Conferred by Overexpressing bfr2^+/pad1^+/sks1^+or pap1^+Genes and Mediated by bfr1^+Gene Product, a Structural and Functional Homologue of P-Glycoprotein in Schizosaccharomyces pombe
- Development of a Versatile Expression Plasmid Construction System for Aspergillus oryzae and Its Application to Visualization of Mitochondria
- Adenine Auxotrophic Mutants of Aspergillus oryzae : Development of a Novel Transformation System with Triple Auxotrophic Hosts
- Identification and Characterization of Scpl5, a Protein from Streptomyces coelicolor A3(2) Inducing Neurites in PC12 Cells(Biochemistry & Molecular Biology)
- Functional Expression in Aspergillus oryzae of p15, a Protein with Potent Neurite-inducing Activity in PC12 Cells(Microbiology & Fermentation Technology)
- Characterization of a Novel Fungal Protein, p15, Which Induces Neuronal Differentiation of PC12 Cells
- S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans I. Producing Strain, Fermentation, Isolation and Biological Activity
- Identification and Characterization of Porcine NP-190, a Novel Protein That Is Specifically Expressed in the Axonal Membrane during the Embryonic Period^1
- Isolation and Characterization of a 230 kDa Protein(p230) Specifically Expressed in Fetal Brains: Its Involvement in Neurite Outgrowth from Rat Cerebral Cortex Neurons Grown on Monolayer of Astrocytes
- Hop-Resistant Lactobacillus brevis Contains a Novel Plasmid Harboring a Multidrug Resistance-Like Gene
- Identification and Characterization of an Intracellular Lectin, Calnexin, from Aspergillus oryzae Using N-Glycan-Conjugated Beads
- Development of a Modified Positive Selection Medium That Allows to Isolate Aspergillus oryzae Strains Cured of the Integrated niaD-Based Plasmid
- Visualizing Nuclear Migration during Conidiophore Development in Aspergillus nidulans and Aspergillus oryzae : Multinucleation of Conidia Occurs through Direct Migration of Plural Nuclei from Phialides and Confers Greater Viability and Early Germination i
- Effects of Protein Transport Inhibitors on the Distribution and Secretion of the Fusion Protein RntA-EGFP in Aspergillus oryzae
- In vivo Visualization of the Distribution of a Secretory Protein in Aspergillus oryzae Hyphae Using the RntA-EGFP Fusion Protein(Microbiology & Fermentation Technology)
- Visualization of Nuclei in Aspergillus oryzae with EGFP and Analysis of the Number of Nuclei in Each Conidium by FACS(Microbiology & Fermentation Technology)
- Production and Product Quality Assessment of Human Hepatitis B Virus Pre-S2 Antigen in Submerged and Solid-State Cultures of Aspergillus oryzae
- Inhibition of Mitochondrial Fragmentation during Sake Brewing Causes High Malate Production in Sake Yeast(BREWING AND FOOD TECHNOLOGY)
- Brewing Properties of Sake Yeast Whose EST2 Gene Encoding Isoamyl Acetate-Hydrolyzing Esterase Was Disrupted
- Molecular Cloning and Nucleotide Sequence of the Isoamyl Acetate-Hydrolyzing Esterase Gene (EST2) from Saccharomyces cerevisiae : The Mechanism of Isoamyl Acetate Production by Sake Yeast (IV)
- Ethanol stress stimulates the Ca^-mediated calcineurin/Crz1 pathway in Saccharomyces cerevisiae(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Enhancement of mitochondrial gene expression in the liver of primary biliary cirrhosis
- Improvement of Heterologous Protein Production in Aspergillus oryzae by RNA Interference with α-Amylase Genes
- Cloning and Overexpression of β-N-Acetylglucosaminidase Encoding Gene nagA from Aspergillus oryzae and Enzyme-catalyzed Synthesis of Human Milk Oligosaccharide(Microbiology & Fermentation Technology)
- Cloning and Characterization of the nagA Gene that Encodes β-N-Acetylglucosaminidase from Aspergillus nidulans and Its Expression in Aspergillus oryzae(Microbiology & Fermentation Technology)
- The Effect of Pyruvate Decarboxylase Gene Knockout in Saccharomyces cerevisiae on L-Lactic Acid Production
- D-Lactic Acid Production by Metabolically Engineered Saccharomyces cerevisiae(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Cloning of a Novel Tyrosinase-Encoding Gene (melB) from Aspergillus oryzae and Its Overexpression in Solid-State Culture (Rice Koji)(BREWING AND FOOD TECHNOLOGY)
- Sialadenitis in patients with chronic hepatitis C is not directly related to hepatitis C virus
- Prevalence of ulcerative colitis and Crohn's disease in Japan
- Mucosal T cells as a target for treatment of IBD
- Chronic Hepatitis B with Flare Due to Co-infection of Hepatitis Delta Virus during Lamivudine Therapy
- Helicobacter pylori DNA in Drinking Water in Japan
- Immunosuppressive agents in the treatment of Crohn's disease and ulcerative colitis
- CD4^+ Intestinal mucosal lymphocytes in the pathogenesis of Crohn's disease
- Ejaculation Timing of Eupyrene and Apyrene Sperm in the Cabbage White Butterfly Pieris rapae (Lepidoptera : Pieridae) during Copulation
- Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3
- No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases
- Changes of HCV quasispecies during combination therapy with interferon and ribavirin
- Amino acid substitutions in PKR-eIF2 phosphorylation homology domain (PePHD) of hepatitis C virus E2 protein in genotype 2a/2b and 1b in Japan and interferon efficacy
- New therapeutic approaches to hepatitis C virus
- MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis
- ICOS costimulation in inflammatory bowel disease
- Role of the innate immune system in the development of chronic colitis
- Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells
- Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication
- Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication
- A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression
- Fas-ligand and perforin expression in infiltrating cytotoxic T lymphocytes in the liver of chronic hepatitis C
- Extranodal NK/T cell lymphoma, nasal type, of the small intestine diagnosed by double-balloon endoscopy
- Sargramostim in patients with Crohn's disease : results of a phase 1-2 study
- Cloning and Analysis of the AWA1 Gene of a Nonfoaming Mutant of a Sake Yeast
- Amplified Fragment Length Polymorphism of the AWA1 Gene of Sake Yeasts for Identification of Sake Yeast Strains(BREWING AND FOOD TECHNOLOGY)
- Purification and Characterization of Extracellular and Cell Wall Bound β-Glucosidases from Aspergillus kawachii
- Aspergillus oryzae palB^ Encodes a Calpain-Like Protease : Homology to Emericella nidulans PalB and Conservation of Functional Regions
- Number and Size of Eggs in the Three Emerald Damselflies, Lestes sponsa, L. temporalis and L. japonicus : Odonata: Lestidae
- Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision
- Cloning and Characterization of the cpyA Gene Encoding Intracellular Carboxypeptidase from Aspergillus nidulans
- Property of Taka-amylase A with Glu or Asp of the Catalytic Residue Replaced by the Corresponding Amine
- Genetic Analysis of Growth Inhibition of Yeast Cells Caused by Expression of Aspergillus oryzae RNase T1
- Monitoring Global Gene Expression of Proteases and Improvement of Human Lysozyme Production in the nptB Gene Disruptant of Aspergillus oryzae
- Tacrolimus (FK506), a novel immunosuppressive drug for inflammatory bowel disease?
- Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells
- Cloning and Expression of 1,2-α-Mannosidase Gene (fmanIB) from Filamentous Fungus Aspergillus oryzae : in Vivo Visualization of the FmanIBp-GFP Fusion Protein
- Cloning and Characterization of the bipA Gene Encoding ER Chaperone BiP from Aspergillus oryzae
- Cloning, Characterization and Overexpression of a Gene (pdiA) Encoding Protein Disulfide Isomerase of Aspergillus oryzae
- Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection
- Molecular and clinical basis for the regeneration of human gastrointestinal epithelia
- Studies on Ecology and Behavior of Japanese Black Swallowtail Butterflies(Lepidoptera : Papilionidae) : V. Fecundity in Summer Generations
- Studies on Ecology and Behavior of Japanese Black Swallowtail Butterflies. III. Diurnal Tracking Behavior of Adults in Summer Generation
- Do fatty acids influence functions of intestinal dendritic cells?
- Genomics of Aspergillus oryzae
- A Eukaryotic Copper-Containing Nitrite Reductase Derived from a NirK Homolog Gene of Aspergillus oryzae
- Identification and Characterization of an Intracellular Lectin, Calnexin, from Aspergillus oryzae Using N-Glycan-Conjugated Beads
- QTL mapping of sake brewing characteristics of yeast
- Improvement of Heterologous Protein Production in Aspergillus oryzae by RNA Interference with α-Amylase Genes
- Light Represses Conidiation in Koji Mold Aspergillus oryzae
- Purification and Characterization of Termite Endogenous β-1,4-Endoglucanases Produced in Aspergillus oryzae
- Monitoring Global Gene Expression of Proteases and Improvement of Human Lysozyme Production in the nptB Gene Disruptant of Aspergillus oryzae
- Inflammatory bowel disease in children : epidemiological analysis of the nationwide IBD registry in Japan
- ITPA gene variant protects against anemia induced by pegylated interferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C
- Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population
- dffA Gene from Aspergillus oryzae Encodes L-Ornithine N^5-Oxygenase and Is Indispensable for Deferriferrichrysin Biosynthesis(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Automatic measurement of sake fermentation kinetics using a multi-channel gas monitor system(BREWING AND FOOD TECHNOLOGY)
- Mitochondrial Dynamics of Yeast during Sake Brewing(BREWING AND FOOD TECHNOLOGY)
- Analysis of the Pyruvate Permease Gene (JEN1) in Glucose Derepression Yeast (Saccharomyces cerevisiae) Isolated from a 2-Deoxyglucose-tolerant Mutant, and Its Application to Sake Making(Microbiology & Fermentation Technology)
- Sake yeast strains have difficulty in entering a quiescent state after cell growth cessation(BREWING AND FOOD TECHNOLOGY)
- Ethanol fermentation driven by elevated expression of the G_1 cyclin gene CLN3 in sake yeast(BREWING AND FOOD TECHNOLOGY)
- Lack of endoplasmic reticulum 1,2-α-mannosidase activity that trims N-glycan Man_9GlcNAc_2 to Man_8GlcNAc_2 isomer B in a manE gene disruptant of Aspergillus oryzae(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Lack of endoplasmic reticulum 1,2-αmannosidase activity that trims N-glycan Man_9GlcNAc_2 to Man_8GlcNAc_2 isomer B in a manE gene disruptant of Aspergillus oryzae
- Rim15p-mediated regulation of sucrose utilization during molasses fermentation using Saccharomyces cerevisiae strain PE-2(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Accelerated Alcoholic Fermentation Caused by Defective Gene Expression Related to Glucose Derepression in Saccharomyces cerevisiae