Multidrug Resistance Phenotype Conferred by Overexpressing bfr2^+/pad1^+/sks1^+or pap1^+Genes and Mediated by bfr1^+Gene Product, a Structural and Functional Homologue of P-Glycoprotein in Schizosaccharomyces pombe

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概要

• 論文の詳細を見る

• We investigated the mechanism of multidrug resistance conferred by overexpression of bfr2^+/pad1^+/sks1^+ or pap1^+ genes of Schizosaccharomyces pombe. Overexpression of bfr2^+ did not confer multidrug resistance on a pap1-disrupted strain. In a mutant with bfr1^+ (a putative membrane transporter which belongs to the ATP-binding cassette superfamily) disrupted, overexpression of either bfr2^+ or pap1^+ did not confer multidrug resistance. These findings suggest that bfr1^+ acts as the most downstream effector of the multidrug resistance conferred by bfr2^+ and pap1^+ genes.

• 社団法人日本農芸化学会の論文
• 1998-02-23

著者

• Kitamoto Katsuhiko

  Department of Biotechnology, The University of Tokyo

• Yamasaki M

  Department Of Biotechnology The University Of Tokyo:(present Address)department Of Food Science And

• Yamashita Masahiro

  Department Of Bioengineering Tokyo Institute Of Technology

• YAMASAKI Makari

  College of Bioresource Sciences, Department of Food Science and Technology, Nihon Universitry

• ARIOKA Manabu

  Corresponding author. Department of Biotechnology, University of Tokyo

• KOUHASHI Mutsuo

  Department of Biotechnology, University of Tokyo

• YODA Koji

  Department of Biotechnology, University of Tokyo

• TAKATSUKI Akira

  Institute of Physical and Chemical Research(RIKEN)

• Arioka Manabu

  Department Of Biotechnology University Of Tokyo

• Arioka M

  Department Of Biotechnology The University Of Tokyo

• Arioka Manabu

  東京大学

• Yoda K

  Univ. Tokyo Tokyo Jpn

• Kitamoto K

  Univ. Tokyo Tokyo Jpn

• Kitamoto K

  National Research Institute Of Brewing

• Kitamoto Katsuhiko

  Dep. Of Biotechnology Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo

• Kouhashi Mutsuo

  Department Of Biotechnology University Of Tokyo

• Takatsuki Akira

  Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)

• Yamane K

  Univ. Tsukuba

• Kitamoto Katsuhiko

  Department Of Biotechnology University Of Tokyo

• Yoda Koji

  Department Of Agricultural Chemistry The University Of Tokyo

• Yamasaki Makari

  Advanced Research Institute For The Science And Humanities Nihon University

• Yamasaki Makari

  College Of Bioresource Sciences Department Of Food Science And Technology Nihon University

• Kitamoto Katsuhiko

  National Research Institute Of Brewing:(present Address)department Of Biotechnology The University O

• Takatsuki A

  Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)

• Kitamoto Katsuhiko

  Department Of Applied Biological Chemistry And Department Of Applied Biological Engineering Graduate

• Kimura K

  Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokkaido University

• Yoda K

  Institute Of Biological Sciences University Of Tsukuba

• Yamasaki Makari

  College of Bioresource Science, Department of Food Science and Technology, Nihon University

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