Defect in Cell Wall Integrity of the Yeast Saccharomyces cerevisiae Caused by a Mutation of the GDP-mannose Pyrophosphorylase Gene VIG9

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概要

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• The Saccharomyces cerevisiae VIG9 gene encodes GDP-mannose pyrophosphorylase, which synthesizes GDP-mannose from GTP and mannose-1-phosphate. Although the null mutant was lethal, the vig9 mutants so far obtained showed no growth defect but immature protein glycosylation and drug hypersensitivity. During our search for cell-wall mutants, we found a novel temperature-sensitive mutant, JS30,which required an osmotic stabilizer for viability. JS30 excreted cell surface proteins in the medium without any indication of cell lysis. Although conventional genetic analysis using mating was impossible, by detailed characterization of JS30 including an in vitro enzyme assay and nucleotide sequencing, we found the defect of JS30 was due to a mutation in the VIG9 gene. These results indicated a critical role of GDP-mannose in maintenance of cell-wall integrity.

• 社団法人日本農芸化学会の論文
• 2000-09-23

著者

• Yamasaki M

  Department Of Biotechnology The University Of Tokyo:(present Address)department Of Food Science And

• Yamashita Masahiro

  Department Of Bioengineering Tokyo Institute Of Technology

• YAMASAKI Makari

  Department of Agricultural Chemistry, the University of Tokyo

• Hashimoto H

  Bio Research Corporation Of Yokohama

• Hashimoto Hitoshi

  Materials Research Institute For Sustainable Development National Institute Of Advanced Industrial S

• YODA Koji

  Department of Biotechnology, University of Tokyo

• Yoda K

  Univ. Tokyo Tokyo Jpn

• NODA Yoichi

  Department of Biotechnology, University of Tokyo

• HASHIMOTO Hitoshi

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University

• Yamane K

  Univ. Tsukuba

• Noda Y

  Univ. Tokyo Tokyo Jpn

• Noda Y

  Department Of Gynecology And Obstetrics Kyoto University Faculty Of Medicine

• HASHIMOTO Hitoshi

  Bio Research Corporation of Yokohama

• Yoda Koji

  Department Of Agricultural Chemistry The University Of Tokyo

• ABE Masato

  Department of Chemical Engineering, Kyoto University

• Yamasaki Makari

  Advanced Research Institute For The Science And Humanities Nihon University

• Yamasaki Makari

  Department Of Agricultural Chemistry The University Of Tokyo

• Yamasaki Makari

  Department Of Biotechnology University Of Tokyo

• Hashimoto H

  Materials Research Institute For Sustainable Development National Institute Of Advanced Industrial S

• Hashimoto Hitoshi

  Res. Inst. For Sustainable Materials National Inst. Of Advanced Industrial Sci. And Technol.

• Shimizu Jiro

  Department of Agricultural Chemistry, The University of Tokyo

• KAWADA Tsuyoshi

  Department of Biotechnology, The University of Tokyo

• KAIBARA Chiaki

  Department of Biotechnology, The University of Tokyo

• FUJIE Akihiko

  Department of Biotechnology, The University of Tokyo

• TOMISHIGE Nario

  Department of Biotechnology, The University of Tokyo

• Abe Masato

  Department Of Chemical Engineering Kyoto University

• Hashimoto H

  Kyoto Inst. Technol. Kyoto Jpn

• Shimizu Jiro

  Department Of Biotechnology The University Of Tokyo

• Shimizu Jiro

  Department Of Agricultural Chemistry The University Of Tokyo

• Fujie Akihiko

  Department Of Biotechnology The University Of Tokyo

• Kaibara Chiaki

  Department Of Biotechnology The University Of Tokyo

• Noda Yoichi

  Department Of Biotechnology University Of Tokyo

• Kawada T

  Department Of Biotechnology The University Of Tokyo

• Hashimoto H

  Department Of Biotechnology The University Of Tokyo

• Hashimoto Hitoshi

  Department Of Marine Science And Technology Tokai University

• Yoda K

  Institute Of Biological Sciences University Of Tsukuba

• Tomishige Nario

  Department Of Biotechnology The University Of Tokyo

• Abe Masato

  Department Of Biotechnology The University Of Tokyo

• Hashimoto Hitoshi

  Department Of Biotechnology The University Of Tokyo

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