Effects of Microbial Products on Glucose Consumption and Morphology of Macrophages

スポンサーリンク

概要

• 論文の詳細を見る

• We studied the effects of microbial products on glucose consumption and morphology of macrophages which were elicited with thioglycollate medium. Macromolecules such as lipopolysaccharide (LPS), tumor promoters, and respiratory inhibitors increased macrophage glucose consumption without inducing evident morphological changes. The assay system was used to screen for active substances in culture broth extracts from actinomycetes. Among them, aureothin increased glucose consumption of macrophages and inhibited respiration of a rat mitochondrial fraction. Concanamycin A induced morphological changes of macrophages into needle-like shapes but not of cloned cells including the macrophage-like cells J774.1. This compound changed fibrosarcoma L929 cells into round shapes without affecting the shape of a nontransformed fibroblast, BALB/3T3 cells. Antimycin and concanamycin A increased tumor-killing activity of macrophages when added during the effector phase. These results suggest that this assay system is simple and sufficiently reproducible and thus usable for screening for modulators of macrophage function among natural products.

• 社団法人日本農芸化学会の論文
• 1993-10-23

著者

• Magae Junji

  Radiation Safety Research Center, Central Institute of Electric Power Industry

• Yamasaki M

  Department Of Biotechnology The University Of Tokyo:(present Address)department Of Food Science And

• Yamashita Masahiro

  Department Of Bioengineering Tokyo Institute Of Technology

• HANADA Toshihiko

  Department of Biotechnology, The University of Tokyo

• MUNEMURA Kazuko

  Department of Agricultural Chemistry, the University of Tokyo

• ENDO Toyoshige

  Department of Pharmaceutical Science, Kyoritsu College of Pharmacy

• YAMASAKI Makari

  Department of Agricultural Chemistry, the University of Tokyo

• MAGAE Junji

  Department of Bioengineering, Tokyo Institute of Technology

• NAGAI Kazuo

  Department of Bioengineering, Tokyo Institute of Technology

• Ichikawa Chiyo

  Department of Pharmaceutical Science, Kyoritsu College of Pharmacy

• Osada Kazuko

  Department of Pharmaceutical Science, Kyoritsu College of Pharmacy

• Tsuji Ryohei

  Department of Agricultural Chemistry, the University of Tokyo

• Hino Ayako

  Department of Bioengineering, Tokyo Institute of Technology

• Horiuchi Tatsuo

  Noda Institute for Scientific Research

• Uramoto Masakazu

  RIKEN, The Institute of Physical and Chemical Research

• Magae J

  Tokyo Inst. Technol. Yokohama Jpn

• Magae Junji

  京都府立医科大学 麻酔学

• Magae Junji

  Dep. Of Biotechnology Inst. Of Res. And Innovation

• Magae Junji

  Radiation Safety Research Center Central Institute Of Electric Power Industry

• Magae J

  Inst. Res. And Innovation Kashiwa Jpn

• Hanada T

  Univ. Tokyo Tokyo Jpn

• Hanada Toshihiko

  Department Of Biotechnology The University Of Tokyo

• Uramoto M

  Riken (the Institute Of Physical And Chemical Research)

• Uramoto M

  Tamagawa Univ. Tokyo Jpn

• Uramoto M

  Department Of Applied Biological Chemistry Tamagawa University

• Ueki Masashi

  Riken Institute

• ICHIKAWA CHIYO

  Fermentation Development Laboratories, Fujisawa Pharmaceutical Co.Ltd.

• URAMOTO Masakazu

  The Institute of Physical and Chemical Research

• Uramoto Masakazu

  Faculty Of Agriculture Tamagawa University Tamagawa Gakuen

• Endo T

  Department Of Pharmaceutical Science Kyoritsu College Of Pharmacy

• Yamasaki Makari

  Advanced Research Institute For The Science And Humanities Nihon University

• Yamasaki Makari

  Department Of Agricultural Chemistry The University Of Tokyo

• Osada Kazuko

  Department Of Dermatology Gifu University School Of Medicine

• Osada Kazuko

  Department Of Pharmaceutical Science Kyoritsu College Of Pharmacy

• Horiuchi T

  Noda Institute For Scientific Research

• Hino Ayako

  Department Of Bioengineering Tokyo Institute Of Technology

• Ichikawa Chiyo

  Fermentation Development Laboratories Fujisawa Pharmaceutical Co.ltd.

• Ichikawa Chiyo

  Department Of Pharmaceutical Science Kyoritsu College Of Pharmacy

• Nagai Kazuo

  Department Of Applied Biological Chemistry Chubu University

• Nagai K

  Chubu Univ. Aichi Jpn

• Munemura Kazuko

  Department Of Agricultural Chemistry The University Of Tokyo

• Uramoto Masakazu

  Riken (the Institute Of Physical And Chemical Research)

• Endo Toyoshige

  Department Of Pharmaceutical Science Kyoritsu College Of Pharmacy

• Tsuji R

  Noda Inst. Scientific Res. Chiba Jpn

• Tsuji Ryohei

  Department of Agricultrual Chemistry, The University of Tokyo

関連論文

• Enhancement of paclitaxel-induced apoptosis in HER2-overexpressing human breast cancer cells by a pertuzumab mimetic peptide, HRAP(MEDICAL BIOTECHNOLOGY)
• S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans II. Structure Elucidation
• Selective Induction of Interleukin-1 Production and Tumor Killing Activity of Macrophages Through Apoptosis by the Inhibition of Oxidative Respiration
• Suppression of T Cell Stimulating Function of Allogeneic Antigen Presenting Cells by Prodigiosin 25-C
• Immunosuppressive Activity of Streptonigrin in Vitro and in Vivo
• Prodigiosin 25-C Perturbs Permeation of Acetate in a Cultured Cell Line
• Presentation of Exogenous Antigen by Macrophages But Not by Spleen Cells Is Inhibited by Leupeptin and Antipain
• Development and Characterization of Macrophage Hybridomas Derived from Murine Peritoneal Exudate Cells
• Effects of Microbial Products on Glucose Consumption and Morphology of Macrophages
• Melastin, a Novel Product of Streptomyces That Selectively Inhibits Leukemia Cell Growth
• Morphological Changes and Reorganization of Actinfilaments in Human Myeloid Leukemia Cells Induced by a Novel Protein Phosphatase Inhibitor, Tautomycin
• Effects of L-156,602,a C5a Receptor Antagonist, on Mouse Experimental Models of Inflammation
• Preferential Suppression of Delayed-type Hypersensitivity by L-156,602,a C5a Receptor Antagonist
• A Novel in Vivo Screening Method for Immunomodulating Substances : Development of an Assay System
• Multidrug Resistance Phenotype Conferred by Overexpressing bfr2^+/pad1^+/sks1^+or pap1^+Genes and Mediated by bfr1^+Gene Product, a Structural and Functional Homologue of P-Glycoprotein in Schizosaccharomyces pombe
• Characterization of a Novel Fungal Protein, p15, Which Induces Neuronal Differentiation of PC12 Cells
• S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans I. Producing Strain, Fermentation, Isolation and Biological Activity
• Identification and Characterization of Porcine NP-190, a Novel Protein That Is Specifically Expressed in the Axonal Membrane during the Embryonic Period^1
• Isolation and Characterization of a 230 kDa Protein(p230) Specifically Expressed in Fetal Brains: Its Involvement in Neurite Outgrowth from Rat Cerebral Cortex Neurons Grown on Monolayer of Astrocytes
• Hop-Resistant Lactobacillus brevis Contains a Novel Plasmid Harboring a Multidrug Resistance-Like Gene
• TmrB Protein, Which Confers Resistance to Tunicamycin on Bacillus subtilis, Binds Tunicamycin
• The Gene Responsible for Tunicamycin Resistance, tmrB, in Bacillus subtilis(Microbilolgy & Fermentation Industry)
• Pressure Effects on an S = 1 Haldane Compound Ni(C_5H_N_2)_2N_3(PF_6)
• Pressure Effects on an S=1 Haldane Compound Ni(C_5H_N_2)_2N_3(PF_6)
• Folimycin (concanamycin A) and Bafilomycin A_1, Inhibitors Specific for V-ATPase,Exert Similar but Distinct Effects on Intracellular Translocation and Processing of Glycoproteins
• Folimycin (Concanamycin A), a Specific Inhibitor of V-ATPase, Blocks Intra-cellular Translocation of the Glycoprotein of Vesicular Stomatitis Virus before Arrival to the Golgi Apparatus
• PPARγ Activation and Adipocyte Differentiation Induced by AS-6, a Prenyl-phenol Antidiabetic Antibiotic
• Induction of Two Types of Gene Amplification by a Cloned DNA Fragment and Amplification of a Foreign Gene on the Bacillus subtilis Chromosome by Using the Fragment
• Amplification of an Integration Plasmid Introduced into the tmr A Amplification Unit of A Bacillus subtitis Tunicamycin-resistant Mutant
• Construction of New ARSI Vectors with Increased Mitotic Stability in Saccharomyces cerevisiae(Microbiology & Fermentation Industry)
• Mutational Site in Tunicamycin-resistant Mutation tmrB8 of Bacillus subtilis as Revealed at the Nucleotide Sequence Level(Microbiology & Fermentation Industry)
• Efficacies of Different Secretion Vectors for Secretion of Human Epidermal Growth Factor by Escherichia coli(Biological Chemistry)
• Substrate Specificity of Acid Proteinase A from Aspergillus niger var. macrosporus
• Novel Saccharomyces cerevisiae Temperature-sensitive cyrl Mutant Which Accumulates Glycogen Particles
• recE-Dependent Gene Amplification Induced by a Tunicamycin-resistant Mutation (tmrA7) in Bacillus subtilis(Microbiology & Fermentation Industry)
• Expression and Secretion of Human Epidermal Growth Factor in Escherichia coli(Microbiology & Fermentation Industry)
• Sequence of the Signal Peptide of E. coli Alkaline Phosphatase
• Structure-Activity Relationship within a Series of Degradation Products of Tautomycin
• Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats
• Dose-Dependent Effect of Dietary Conjugated Linoleic Acid on the Growth of Rat Hepatoma dRLh-84 Cells In Vivo
• Magnetic-Field-Induced Freezing of Spin Correlations in Networked System of [Mn_4] Single-Molecule Magnets(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Two-Dimensional Coordination Networks of [Mn_4] Single-Molecule Magnets : Heat Capacity Measurements(Condensed matter : structure and mechanical and thermal properties)
• Evaluation of Insulin Permeability and Effects of Absorption Enhancers on Its Permeability by an in Vitro Pulmonary Epithelial System Using Xenopus Pulmonary Membrane
• Systematic Synthesis of Porphyrin Dimers Linked by Conjugated Oligoacetylene Bridges
• Pyrene-Fused Porphyrins : Annulation Reactions of meso-Pyrenylporphyrins
• Fas Ligand Released by Activated Monocytes Causes Apoptosis of Lung Epithelial Cells in Human Acute Lung Injury Model in Vitro(Molecular and Cell Biology)
• Identification of Low Molecular Weight Probes on Perforin- and Fas-based Killing Mediated by Cytotoxic T Lymphocytes
• Costunolide and Dehydrocostus Lactone as Inhibitors of Killing Function of Cytotoxic T LymPhocytes
• 1'-Acetoxychavicol Acetate as an Inhibitor of Phagocytosis of Macrophages
• Prodigiosin 25-C Suppression of Cytotoxic T Cells in Vitro and in Vivo Similar to That of Concanamycin B, a Specific Inhibitor of Vacuolar Type H^+-ATPase
• Screening for Specific Inhibitors of Phagocytosis of Thioglycollate-elicited Macrophages
• Raman Scattering by Ethylenediamines in Quasi-One-Dimensional Mixed-Valence Complexes [M (en)_2][Pt (en)_2Cl_2](ClO_4)_4(M=Pt,Pd,en=ethylenediamine)
• Molecular Cloning of a Gene, DHS1, Which Complements a Drug-hypersensitive Mutation of the Yeast Saccharomyces cerevisiae
• Aberrant Expression of Fra-1 in Estrogen Receptor-negative Breast Cancers and Suppression of their Propagation In Vivo by Ascochlorin, an Antibiotic that Inhibits Cellular Activator Protein-1 Activity
• A Square Cyclic Porphyrin Dodecamer : Synthesis and Single-Molecule Characterization
• Tuning of Electronic Structures of Quasi-One-Dimensional Bromo-Bridged Pd^-Pd^ Mixed-Valence Complexes by Substituting Counter Anions
• Versatile Vapochromic Behavior Accompanied by a Phase Change between Charge-Polarization State and Charge-Density-Wave State in a Quasi-One-Dimensional Iodo-Bridged Dinuclear Platinum Mixed-Valence Compound, [{NH_3(CH_2)_5NH_3}_2]-[Pt_2(pop)_4I]・4H_2O
• Metal-Metal Bonded Diruthenium Unit Axial-Capped by Di-tert-butylphenolate : [Ru_2(O_2CCH_3)_2(t-Busal-R'py)_2]^- (t-Busal-R'py^ = N-(R'-2-pyridyl)-2-oxido-3,5-di-tert-butylbenzylaminato ; R' = H, 4-Me, and 5-Me)
• New Charge-transfer Salts Based on Unsymmetrical Donor DMET and Metal Complex Anions : (DMET)_3[Cr(isoq)_2(NCS)_4] and (DMET)_3[Cr(phen)(NCS)_4]・CH_3CN
• Synthesis and Structural Determination of a Porphyrinatoplatinum(II) : meso-Tetrakis(4-t-butylphenyl)porphyrinatoplatinum(II)
• 23pWX-6 Scanning Tunneling Microscopy Investigation of tris(phthalocyaninato)yttrium triple-decker molecules deposited on Au(111)
• Reduced Expression of Perchloric Acid-Soluble Protein after Partial Hepatectomy in Rats
• Oxidative Stress by Visible Light Irradiation Suppresses Immunoglobulin Production in Mouse Spleen Lymphocytes
• Dietary Conjugated Linoleic Acid Increases Immunoglobulin Productivity of Sprague-Dawley Rat Spleen Lymphocytes
• Dietary Effect of Conjugated Linoleic Acid on Lipid Levels in White Adipose Tissue of Sprague-Dawley Rats
• Immunosuppressive Activity of 4-O-Methylascochlorin
• Elimination of Cell-cycle Regulators during Caspase-3-dependent Apoptosis Caused by an Immunosuppressant, FTY720(Biochemistry & Molecular Biology)
• Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice(Food & Nutrition Science)
• Dietary Manipulations of Body Fat-reducing Potential of Conjugated Linoleic Acid in Rats(Food & Nutrition Science)
• Defect in Cell Wall Integrity of the Yeast Saccharomyces cerevisiae Caused by a Mutation of the GDP-mannose Pyrophosphorylase Gene VIG9
• Molecular Characterization of a Novel Yeast Cell-wall Acid Phosphatase Cloned from Kluyveromyces marxianus
• Distinct Interaction of TmrB Protein with Membranes in Bacillus subtilis and Escherichia coli
• Synthesis, Structure, and Reactivities of the η^1:η^6-μ_2-Aryl Alkynyl Diruthenium Complex. X-Ray Structure of [CP(PPh_3)_2Ru(η^1:η^6-μ_2-C≡CC_6H_4Me-p)RuCp*]PF_6(Cp=η_5-C_5H_5, Cp*=η_5-C_5Me_5)
• A Surface-Silylated Single-Layer Resist Using Chemical Amplification for Deep Ultraviolet Lithography:II. Limited Permeation of Si Compounds from Liquid Phase^* : Instrumentation, Measurement, and Fabrication Technology
• Cloning Genomic DNA Encoding Apple Polyphenol Oxidase and Comparison of the Gene Product in Escherichia coli and in Apple
• Purification and Characterization of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) Derivatives : KW-2228 and Other Derivatives
• Syntheses, Crystal Structure, and Magnetic Properties of Mn_ Single-Molecule Magnets with Naphthalenecarboxylate Bridges, [Mn_O_(O_2CC_H_7)_(H_2O)_4] and Their Tetraphenyl-phosphonium Salts
• Effects of Nonthermal Processes on the Inactivation of Microorganisms and Antioxidants in Minimally Processed Vegetables
• Metal Valence Structures and Magnetic Interactions in Halogen-Bridged 1-D Ni-Pd Mixed-Metal Complexes Studied by ^C and ^1H Solid State NMR
• Ultrafast Optical Responses in a One-Dimensional Mott Insulator of a Br-Bridged Ni Compound(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Ultrafast Photoconversion from Charge Density Wave State to Mott-Hubbard State in One-Dimensional Extended Peierls-Hubbard System of Br-Bridged Pd Compound(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Construction of a One-Dimensional Chain Composed of Mn_6 Clusters and 4,4'-Bipyridine Linkers: The First Step for Creation of "Nono-Dots-Wires"
• Pressure Effect of an S=1 Haldane Compound NDMAZ : Condensed Matter: Electronic Properties, etc.
• A Novel Mn_ Single-molecule Magnet with a μ_3-Methanesulfonate Bridge
• A Chemical Modification of a Mn_ Single-Molecule Magnet by Replacing Carboxylate Anions with Diphenylphosphate Anions
• Biofilm formation by Escherichia coli in hypertonic sucrose media(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• High-Hydrostatic-Pressure Treatment Impairs Actin Cables and Budding in Saccharomyces cerevisiae (MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• High Hydrostatic Pressure Treatment Impairs AcrAB-TolC Pump Resulting in Differential Loss of Deoxycholate Tolerance in Escherichia coli(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Estimation of the Biofilm Formation of Escherichia coli K-12 by the Cell Number(Environmental Biotechnology)
• High Pressure Carbon Dioxide Decreases the Heat Tolerance of the Bacterial Spores
• Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants of Escherichia coli(Microbiology & Fermentation Technology)
• Effect of High Pressure Gaseous and Supercritical Carbon Dioxide Treatments on Bacterial Spores
• Cladribine Enhances Apoptotic Cell Death in Lung Carcinoma Cells Over-Expressing DNase γ
• KJ1 Development of Neu-up, a Human G-CSF Derivative with Higher Specific Activity
• Mixed-Species Biofilm Formation by Direct Cell-Cell Contact between Brewing Yeasts and Lactic Acid Bacteria
• Ferromagnetic Assemblies Composed of Mn^ Salen-Type Complexes and a Tripodal Fe^ Complex with an Imidazolate Bridge
• Cytoplasmic Acidification May Occur in High-Pressure Carbon Dioxide-Treated Escherichia coli K12
• Cell-Cycle Independent Chromosome Condensation in Schizosaccharomyces pombe Induced by High Hydrostatic Pressure Treatment
• Cessation of Cytokinesis in Schizosaccharomyces pombe during Growth after Release from High Hydrostatic Pressure Treatment
• Improved Production and Recovery of Alkaline Elastase from Alkalophilic Bacillus Strain by a Change of Medium Composition

もっと見る 閉じる

スポンサーリンク