Enhancement of paclitaxel-induced apoptosis in HER2-overexpressing human breast cancer cells by a pertuzumab mimetic peptide, HRAP(MEDICAL BIOTECHNOLOGY)

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概要

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• HRAP, a pentapeptide designed to bind with the pertuzumab interacting site in an extracellular domain of the HER2 molecule, enhanced the cytotoxicity of paclitaxel in HER2-overexpressing human breast cancer cell lines, BT474 and SKBR-3, but not in MDA-231 cells, which express lower levels of HER2. HRAP enhanced mitochondria-dependent apoptosis induced by paclitaxel in SKBR-3 and BT-474, but not in MDA-231. HRAP enhanced the inhibition of phosphorylation of serine 473 in Akt and Ser380/Thy382/The383 in PTEN. These results suggest that HRAP enhances paclitaxel-induced apoptosis in a manner dependent on the PTEN/Akt signal transduction pathway.

著者

• Nakajima Hiroo

  Tsujigiwa Daigo Clinic

• Mizuta Naruhiko

  Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine

• Sakaguchi Koichi

  Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine

• Fujiwara Ikuya

  Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine

• Yoshimori Atsushi

  Department of Biochemistry, Tokyo University of Science

• Magae Junji

  Radiation Safety Research Center, Central Institute of Electric Power Industry

• Tanuma Sei-ichi

  Department of Biochemistry, Tokyo University of Science

• Magae Junji

  京都府立医科大学 麻酔学

• Magae Junji

  Dep. Of Biotechnology Inst. Of Res. And Innovation

• Magae Junji

  Radiation Safety Research Center Central Institute Of Electric Power Industry

• Magae J

  Inst. Res. And Innovation Kashiwa Jpn

• Nakajima Hiroo

  京都府立医科大学 内分泌･乳腺外科学部門

• Fujiwara Ikuya

  Department Of Endocrine And Breast Surgery Kyoto Prefectural University Of Medicine

• Fujiwara Ikuya

  京都府立医科大学 内分泌･乳腺外科学部門

• Mizuta Naruhiko

  京都府立医科大学 内分泌･乳腺外科学部門

• Mizuta Naruhiko

  Department Of Endocrine And Breast Surgery Kyoto Prefectural University Of Medicine

• Yoshimori Atsushi

  京都府立医科大学 内分泌･乳腺外科学部門

• Yoshimori Atsushi

  Department Of Biochemistry Tokyo University Of Science

• Yoshimori Atsushi

  Institute For Theoretical Medicine Inc.

• Sakaguchi Koichi

  Department Of Endocrine And Breast Surgery Kyoto Prefectural University Of Medicine

• Sakaguchi Koichi

  京都府立医科大学 内分泌･乳腺外科学部門

• Tanuma Sei-ichi

  東京理科大学 薬学部生化学

• Tanuma Sei-ichi

  京都府立医科大学 内分泌･乳腺外科学部門

• Tanuma Sei-ich

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Tanuma S

  Department Of Biochemistry Tokyo University Of Science

• Yoshimori Atsushi

  Dep. Of Biochemistry Tokyo Univ. Of Sci. 2641 Yamazaki Noda Chiba 278-8510 Jpn

• Magae J

  Department Of Biotechnology Institute Of Research And Innovation (iri)

• Tanuma S

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• Tanuma Sei-ichi

  Department Of Electronics Faculty Of Technology Gunma University:department Of Materials Science Iwa

• Mizuta Naruhiko

  辻際醍醐診療所

• Sakaguchi Koichi

  Department Of Chemistry Tokyo Metropolitan University

• Tanuma Sei-ichi

  Department Of Biochemistry Faculty Of Pharmaceutical Science Science University Of Tokyo

• TANUMA Sei-ichi

  The Institute for Solid State Physics, The University of Tokyo

• SAKAGUCHI Koichi

  Department of Chemistry and Applied Chemistry, Faculty of Science and Engineering, Saga University

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