Differentiation of Mouse and Human Myeloid Leukemia Cells Induced by an Antitumor Antibiotic, Ascofuranone(Biological Chemistry)

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概要

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• Mouse myeloid leukemia cells, M1, were induced to differentiate into phagocytes by treatment with ascofuranone (AF). AF also induced differentiation of human promyelocytic leukemia HL60 cells and human erythroid leukemia K562 cells into granulocytes and erythrocytes, as detected by nitroblue tetrazolium reducing activity and benzidine staining, respectively. The antibiotic enhanced acetate incorporation of K562 cells. The increase was not observed with the cells of HL60 and two human B lymphoma lines, Daudi and Raji. The increase was diminished by th addition of a glycolysis inhibitor, deoxyglucose. Inhibitors of repsiration, antimycin and sodium azide, also enhanced acetate incorporation of K562 cells specifically, which was diminished by the addition of deoxyglucose. Furthermore, antimycin induced differentiation of K562 and HL60 cells. These results suggest a possible relationship between cell differentiation and inhibition of respiration.

• 社団法人日本農芸化学会の論文
• 1988-12-23

著者

• Magae J

  Tokyo Inst. Technol. Yokohama Jpn

• Magae J

  Inst. Res. And Innovation Kashiwa Jpn

• Tamura G

  Department Of Agricultural Chemistry The University Of Tokyo

• Tamura G

  Nuclear Receptor Institute Ksp

• TAMURA Gakuzo

  Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo

• Tamura Gakuzo

  Nuclear Receptor Institute Ksp

• MAGAE Junji

  Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo

• NAGAI Kazuo

  Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo

• ANDO Kunio

  Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo

• Ando K

  Nuclear Receptor Institute Ksp

• Nagai K

  Okayama Univ. Okayama Jpn

• TAMURA Gakuzo

  Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo

• ANDO Kunio

  Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo

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