A New Screening Procedure on Selective Inhibitors against SV40-Transformed Cells
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概要
- 論文の詳細を見る
A comparative study of selective cytotoxicity between non-transformed and SV40-transformed cells has been undertaken in combination with antitumor agents having different mechanisms of action. The selective in vitro cytotoxicity assay (N/T assay) measured the decrease in cell proliferation under the microscope. SV40-transformed cells had higher sensitivity than non-transformed cells against these antitumor agents at low concentration; but an apparent dissimilar pattern of sensitivity was observed in some antimetabolites, such as cytosine arabinoside, 6-mercaptopurine, 5-fluorouracil, and in some inhibitors of energy-transfer. The results can be interpreted in terms of a possible difference in cytotoxicity between non-transformed and SV40-transformed cell lines. The N/T assay may be considered a convenient system for evaluating selective cytotoxicity for in vitro-in vivo comparisons.
- 社団法人 日本農芸化学会の論文
著者
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Takatsuki A
Riken Inst. Physical And Chemical Res. Saitama Jpn
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Tamura G
Department Of Agricultural Chemistry The University Of Tokyo
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TAKATSUKI Akira
Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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TAMURA Gakuzo
Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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MUNEKATA MASANOBU
Laboratory of Microbiology, Department of Agricultural Chemistry, The University of Tokyo
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ONODERA KAZUKIYO
Laboratory of Biological Chemistry, Department of Agricultural Chemistry, The University of Tokyo
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TAKATSUKI Akira
Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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TAMURA Gakuzo
Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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