Effects of Mepanipyrim on Intracellular Trafficking: A Comparative Study on Its Effects on Exocytic and Endocytic Trafficking of Proteins, Sphingolipids, and Cholesterol

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概要

• 論文の詳細を見る

• Mepanipyrim, N-(4-methyl-6-prop-1-ynylpyrimidin-2-yl)aniline, diminished the cell surface expression of envelope glycoproteins of Newcastle disease and vesicular stomatitis viruses at concentrations where their synthesis was not profoundly affected. Intoxication by diphtheria toxin and ricin and recycling of transferrin were not affected even when cells were treated with mepanipyrim for 2 h before the addition of these probes, indicating that mepanipyrim does not act on the endocytic and recycling pathways of these proteins. Metabolic conversion of C_6-NBD-ceramide to sphingomyelin and its back-exchange to the medium was also not affected, but synthesis and back-exchange of C_6-NBD-glucosylceramide were greatly influenced, and an accumulation of LDL-derived, unesterified cholesterol was induced by the drug. These results are discussed relating to the site(s) of action of mepanipyrim.

• 社団法人日本農芸化学会の論文
• 1996-10-23

著者

• TAKATSUKI Akira

  Institute of Physical and Chemical Research(RIKEN)

• Muroi M

  Riken Inst. Physical And Chemical Res. Saitama Jpn

• Muroi Makoto

  Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)

• Muroi Makoto

  Animal And Cellualr Systems Laboratory The Institute Of Physical And Chemical Research (riken)

• Takatsuki A

  Riken Inst. Physical And Chemical Res. Saitama Jpn

• Takatsuki Akira

  Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)

• YAMAGUCHI Isamu

  Microbial Toxicology Laboratory, The Institute of Physical and Chemical Research (RIKEN)

• MIURA Ichiro

  Microbial Toxicology Laboratory, The Institute of Physical and Chemical Research (RIKEN)

• SHIRAGAMI Nobue

  Animal and Cellular Systems Laboratory, The Institute of Physical and Chemical Research (RIKEN)

• Takatsuki Akira

  Animal And Cellualr Systems Laboratory The Institute Of Physical And Chemical Research (riken)

• Yamaguchi Isamu

  Microbial Toxicology Laboratory Riken:(present Address)environmental Plant Research Group Plant Scie

• Takatsuki A

  Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)

• Shiragami Nobue

  Animal And Cellular Systems Laboratory The Institute Of Physical And Chemical Research (riken)

• Yamaguchi Isamu

  Microbial Toxicology Laboratory The Institute Of Physical And Chemical Research (riken)

• Miura Ichiro

  Microbial Toxicology Laboratory The Institute Of Physical And Chemical Research (riken)

• YAMAGUCHI Isamu

  Microbial Toxicology Laboratory and Biodesign Research Group, RIKEN(The Institute of Physical and Chemical Research)

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