Characterization of Glofibrate-induced Retrograde Golgi Membrane Movement to the Endoplasmic Reticulum : Clofibrate Distinguishes the Golgi from the Trans Golgi Network(Biochemistry & Molecular Biology)
スポンサーリンク
概要
- 論文の詳細を見る
Clofibrate-induced retrograde Golgi membrane movement was blocked or retarded when NRK cells were treated with sodium azide/2-deoxy glucose, nocodazole, taxol, and destruxin B, indicating that it depends on energy, and the dynamic state of microtubules, and being acidic or vacuolar-type ATPase function. PDMP and phospholipase A_2 inhibitors also blocked it. These characteristics are similar to those of brefeldin A (BFA) and nordihydroguaiaretic acid (NDGA), inducers of retrograde Golgi membrane movement. However, clofibrate was distinguished from BFA in that BFA action was insensitive to phospholipase A_2 inhibitors and from NDGA in that NDGA stabilized microtubules against nocodazole and its action was almost insensitive to taxol. The trans Golgi network (TGN) was resistant to clofibrate, while BFA and NDGA dispersed it. To our knowledge, clofibrate is the first drug to show such different effects on the Golgi and TGN and, therefore, is expected to be a useful tool to distinguish their architecture and/or membrane dynamics.
- 社団法人日本農芸化学会の論文
- 2001-08-23
著者
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KONO Yoshiki
The Institute of Physical and Chemical Research
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TAKATSUKI Akira
Institute of Physical and Chemical Research(RIKEN)
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Takatsuki A
Riken Saitama Jpn
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Takatsuki Akira
Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)
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NAKAMURA Machiko
Animal and Cellular Systems Laboratory
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KONO Yoshiki
School of Agriculture, Ibaraki University
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KUROIWA Natsuko
Animal and Cellular Systems Laboratory, RIKEN (The Institute of Physical and Chemical Research)
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Kono Y
Ibaraki Univ. Ibaraki Jpn
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Kono Yoshiki
School Of Agriculture Ibaraki University
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Takatsuki Akira
Animal And Cellualr Systems Laboratory The Institute Of Physical And Chemical Research (riken)
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Kuroiwa Natsuko
Animal And Cellular Systems Laboratory Riken (the Institute Of Physical And Chemical Research):schoo
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Nakamura Machiko
Animal And Cellular Systems Laboratory:school Of Agriculture Ibaraki University
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Nakamura M
Riken Saitama Jpn
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Takatsuki A
Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)
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