Mepanipyrim, a Novel Inhibitor of Pharmacologically Induced Golgi Dispersion(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
Mepanipyrim inhibited retrograde Golgi-to-ER trafficking induced by brefeldin A (BFA), nordi-hydroguaiaretic acid, clofibrate, and arachidonyltrifluoromethyl ketone in NRK and other types of cells, but did not inhibit anterograde trafficking of Golgi-resident proteins translocated to ER by BFA and newly synthesized VSV-G. However, mepanipyrim did not block the TGN38 dispersion induced by any of these compounds. Mepanipyrim acted on the Golgi, and swollen vesicular Golgi structures were formed and similar structures accumulated during rebuilding of the Golgi after BFA removal. These actions of mepanipyrim were readily reversed after its removal. Mepanipyrim did not stabilize microtubules, but prevented nocodazole-induced fragmentation and dispersion of the Golgi. These results suggest that the mepanipyrim-sensitive molecules participated in stabilizing the Golgi and its anchoring in the perinuclear region, and equally importantly, that the novel action of mepanipyrim may be used as a pharmacological tool for investigating membrane transport, Golgi membrane dynamics, and differentiation of the Golgi from TGN.
- 社団法人日本農芸化学会の論文
- 2003-01-23
著者
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Takatsuki Akira
Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)
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KONO Yoshiki
School of Agriculture, Ibaraki University
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Kono Yoshiki
School Of Agriculture Ibaraki University
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Takatsuki Akira
Animal And Cellualr Systems Laboratory The Institute Of Physical And Chemical Research (riken)
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NAKAMURA Michiko
Animal and Cellular Systems Laboratory, RIKEN (The Institute of Physical and Chemical Research)
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Nakamura Michiko
Animal And Cellular Systems Laboratory Riken (the Institute Of Physical And Chemical Research):schoo
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TAKATSUKI Akira
Animal and Cellular Systems Laboratory, RIKEN (The Institute of Physical and Chemical Research)
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