Glucosylceramide Synthesis Inhibitors Block Pharmacologically Induced Dispersal of the Golgi and Anterograde Membrane Flow from the Endoplasmic Reticulum : Implication of Sphingolipid Metabolism in Maintenance of the Golgi Architecture and Anterograde Mem

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概要

• 論文の詳細を見る

• PDMP (D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol) and PPMP (D, L-threo-1-phenyl-2- hexadecanoylamino-3-morpholino-1-propanol), inhibitors of glucosylceramide synthesis, blocked brefeldin A (BFA)-and nordihydroguaiaretic acid-induced dispersal of the Golgi and trans Golgi network, and Golgi-derived vesicles were retained in the juxtanuclear region. PDMP and PPMP did not stabilize microtubules but blocked nocodazole-induced extensive fragmentation and dispersal of the Golgi, and large Golgi vesicles were retained in the juxtanuclear region. PPMP is a stronger inhibitor of glucosylceramide synthesis than PDMP, but PDMP showed a stronger activity against BFA-induced retrograde membrane flow. However, PPMP showed a stronger activity for Golgi disruption and inhibition of anterograde trafficking from the endoplasmic reticulum, and rebuilding of the Golgi architecture. Cumulatively, these results suggest that sphingolipid metabolism is implicated in maintenance of the Golgi architecture and anterograde membrane flow from the endoplasmic reticulum but not in Golgi dispersal induced by BFA.

• 社団法人日本農芸化学会の論文
• 2001-06-23

著者

• KONO Yoshiki

  The Institute of Physical and Chemical Research

• TAKATSUKI Akira

  Institute of Physical and Chemical Research(RIKEN)

• Takatsuki A

  Riken Saitama Jpn

• Takatsuki Akira

  Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)

• NAKAMURA Machiko

  Animal and Cellular Systems Laboratory

• KONO Yoshiki

  School of Agriculture, Ibaraki University

• KUROIWA Natsuko

  Animal and Cellular Systems Laboratory, RIKEN (The Institute of Physical and Chemical Research)

• Kono Y

  Ibaraki Univ. Ibaraki Jpn

• Kono Yoshiki

  School Of Agriculture Ibaraki University

• Takatsuki Akira

  Animal And Cellualr Systems Laboratory The Institute Of Physical And Chemical Research (riken)

• Kuroiwa Natsuko

  Animal And Cellular Systems Laboratory Riken (the Institute Of Physical And Chemical Research):schoo

• Nakamura Machiko

  Animal And Cellular Systems Laboratory:school Of Agriculture Ibaraki University

• Nakamura M

  Riken Saitama Jpn

• Takatsuki A

  Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)

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