A Bioactive Polyphenolic Constituent in the Bark of Pterocarpus indicus, Willd. I. Isolation and Characterization
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概要
- 論文の詳細を見る
A nondialyzable polyphenolic substance having antiplasmin activity was isolated from the bark of Pterocarpus indicus, Willd as a brownish powder. The results of ultracentrifuging, HPLC and TLC of its acetate indicated a narrow distribution of its molecular weight, i.e. its relative homogeneity. This observation, and the pattern seen in its 13C-NMR spectrum that indicated a difference of its constituent units from the known coniferous polyflavanols, suggested some uniqueness of this substance (called PI in this paper) in the polyflavanol group. Its large apparent molecular weight, which was calculated from the sedimentation data, also seems to support this suggestion. The substance inhibited plasmin esterolytic activity at ED50 = 2.5 μg/ml, and also showed a carcinostatic effect on mice bearing ascites Ehrlich carcinoma at a dose of 2 mg/kg.
- 社団法人 日本農芸化学会の論文
著者
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KONO Yoshiki
The Institute of Physical and Chemical Research
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Mizutani Takeo
The Institute Of Physical And Chemical Research
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TAKEUCHI Setsuo
The Institute of Physical and Chemical Research
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WATANABE Ryoko
The Institute of Physical and Chemical Research
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KAWARADA Akira
The Institute of Physical and Chemical Research
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Adisewojo Sasongko
The Institute For Natural Sciences Padjadjaran University
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SUZUKI Yoshikatsu
The Institute of Physical and Chemical Research
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MARUYAMA Kokichi
The Institute of Physical and Chemical Research
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NAKAYAMA Reiko
The Institute of Physical and Chemical Research
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HIRAOKA Atsushi
The Institute of Physical and Chemical Research
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