Synthesis and Biological Activity of a New Type of PM-Toxin Analogue Containing Oxygen Atoms in the Carbon-Chain Skeleton
スポンサーリンク
概要
- 論文の詳細を見る
PM-toxins are host-specific pathotoxins produced by the corn fungal pathogen Phyllosticta maydis. Three PM-toxin analogues of a new type which have oxygen atoms in the skeletal carbon chain were synthesized as stereoisomeric mixtures. The linear ester PML-777 was about 100-times less active than the potent synthetic analogue PM-777 in an NADH oxidation assay using corn mitochondria. A large cyclic analogue, PMC32-7777, was only about 4- to 10-times less active than the parent linear ester PML-777, but over 500-times more active than a smaller sized analogue, PMC20-711. The striking loss of biological activity in PML-777 clearly shows the significance of a carbonchain skeleton like PM-777 for higher biological activity. The unexpectedly slight decrease of activity from PML-777 to PMC32-7777 may suggest that the active conformation of the linear analogue (PML-777) was similar to that of the cyclic analogue (PMC32-7777).
- 社団法人 日本農芸化学会の論文
著者
-
KONO Yoshiki
The Institute of Physical and Chemical Research
-
TAKEUCHI Setsuo
The Institute of Physical and Chemical Research
-
Knoche H.
Department Of Biochemistry University Of Nebraska
-
DANKO S.
Department of Agricultural Biochemistry, University of Nebraska
-
Daly J.
Department Of Agricultural Biochemistry University Of Nebraska
-
Danko S.
Department Of Agricultural Biochemistry University Of Nebraska
-
SUZUKI Yoshikatsu
The Institute of Physical and Chemical Research
-
KNOCHE H.
Department of Agricultural Biochemistry, University of Nebraska
関連論文
- Isolation and Identification of (-)-Jasmonic Acid from Wild Rice, Oryza officinalis, as an Antifungal Substance(Organic Chemistry)
- Nordihydroguaiaretic Acid, of a New Family of Microtubule-stabilizing Agents, Shows Effects Differentiated from Paclitaxel(Biochemistry & Molecular Biology)
- Characterization of Glofibrate-induced Retrograde Golgi Membrane Movement to the Endoplasmic Reticulum : Clofibrate Distinguishes the Golgi from the Trans Golgi Network(Biochemistry & Molecular Biology)
- Glucosylceramide Synthesis Inhibitors Block Pharmacologically Induced Dispersal of the Golgi and Anterograde Membrane Flow from the Endoplasmic Reticulum : Implication of Sphingolipid Metabolism in Maintenance of the Golgi Architecture and Anterograde Mem
- New Types of Liposidomycins Produced by Streptomyces that Inhibit Bacterial Peptidoglycan Synthesis Structure Elucidation of Fatty Acid Components by Tandem Mass Spectrometry
- Structural Analyses of Carbon Chains in 5-Alk(en)ylresorcinols of Rye and Wheat Whole Flour by Tandem Mass Spectrometry
- Structures of Oryzalides A and B, and Oryzalic Acid A, a Group of Novel Antimicrobial Diterpenes, Isolated from Healthy Leaves of a Bacterial Leaf Blight-resistant Cultivar of Rice Plant(Organic Chemistry)
- Nonselective Phytotoxins Simultaneously Produced with Host-selective ACTG-toxins by a Pathotype of Alternaria citri Causing Brown Spot Disease of Mandarins
- Studies on Host-selective Toxins Produced by a Pathotype of Alternaria citri Causing Brown Spot Disease of Mandarins(Organic Chemistry)
- A Bioactive Polyphenolic Constituent in the Bark of Pterocarpus indicus, Willd and Its Effects on Animal Cell Phenotypes in Vitro(Biological Chemistry)
- Studies on a Quantitative Analysis of Oryzalides and Oryzalic Acids in Rice Plants by GC-SIM
- Structures of Oryzalic Acid B and Three Related Compounds, a Group of Novel Antibacterial Diterpenes, Isolated from Leaves of a Bacterial Leaf Blight-Resistent Cultivar of Rice
- Novel C_-Kaurane Type of Diterpene (Oryzalide A), a New Antimicrobial Compound Isolated from Healthy Leaves of a Bacterial Leaf Blight-resistant Cultivar of Rice Plant(Organic Chemistry)
- Structures of Two Novel Pyriculol-related Compounds and Identification of Naturally Produced Epipyriculol from Pyricularia oryzae(Organic Chemistry)
- Specific Accumulation of Antifungal 5-Alk(en)ylresorchinol Homologs in Etiolated Rice Seedlings
- Structure of a New Antifungal C_-Hydroxyfatty Acid Isolated from Leaves of Wild Rice (Oryza officinalis)
- Toxic Activity of Mimics of the Host-Specific Pathotoxin PM-Toxin on Corn Carrying Texas Male-sterile Cytoplasm(Organic Chemistry)
- Syntheses and Biological Activities of (±)-Streptovitacin A and E-73(Organic Chemistry)
- Synthesis and Biological Activities of Demethylcycloheximides(Organic Chemistry)
- Preparation of Chiral trans-2,4-Dimethyl-1-cyclohexanones, the Key Intermediates in Cycloheximide Synthesis, Using Microbial Resolution(Organic Chemistry)
- Absolute Structure of (-)-4,5-trans-Dihydroxy-3-methyl-2-cyclopentenone Isolated from the Marine Alga, Grateloupia filicina (Wulfen) J. Agardh by the Synthesis of Both Enantiomers(Organic Chemistry)
- Ankalactone, a New α,β-Unsaturated γ-Lactone from Monascus anka(Organic Chemistry)
- Two New Pyrogallols from the Marine Alga, Grateloupia filicina (Wulfen) J. Agardh(Organic Chemistry)
- Studies on the Conformations of PM-Toxin, the Host-specific Corn Pathotoxin Produced by Phyllosticta maydis(Organic Chemistry)
- Deoxyfunicone, a New γ-Pyrone Metabolite from a Resorcylide-producing Fungus (Penicillium sp.)(Organic Chemistry)
- Structure of HV-toxin M, a Host-specific Toxin-related Compound Produced by Helminthosporium victoriae(Organic Chemistry)
- Structure of HV-toxin M, a Host-specific Toxin-related Compound Produced by Helminthosporium victoriae
- Comparison of Indole-3-acetic Acid Oxidation in Peroxidases from Rust-Infected Resistant Wheat Leaves
- Biosynthetic Study of Chloromonilicin, a Growth Self-inhibitor Having a Novel Lactone Ring, from Monilinia fructicola(Organic Chemistry)
- Chloromonilinic Acids A and B, Novel Catabolites of the Growth Self-inhibitor Chloromonilicin Isolated from Monilinia fructicola(Organic Chemistry)
- Structure of Amino Acids Isolated from Hydrolyzed HV-Toxin M, a Host-specific Toxin-related Compound Produced by Helminthosporium victoriae
- Structure of the Major Component of ACRL-toxins, Host-specific Pathotoxic Compounds Produced by Alternaria citri
- Structure of the Host-selective Toxins Produced by a Pathotype of Alternaria citri Causing Brown Spot Disease of Mandarins
- Absolute Configuration of Oryzalexin A and Structures of Its Related Phytoalexins Isolated from Rice Blast Leaves Infected with Pyricularia oryzae
- A Bioactive Polyphenolic Constituent in the Bark of Pterocarpus indicus, Willd. I. Isolation and Characterization
- Synthesis and Biological Activity of a New Type of PM-Toxin Analogue Containing Oxygen Atoms in the Carbon-Chain Skeleton
- Novel Phytoalexins (Oryzalexins A, B and C) Isolated from Rice Blast Leaves Infected with Pyricularia oryzae. Part I: Isolation, Characterization and Biological Activities of Oryzalexins
- Isolation and Structure of a New Victoxinine Derivative Produced by Helminthosporium victoriae
- Synthesis of a Stereoisomeric Mixture of (±)-PM-Toxin B, a Host-specific Corn Pathotoxin Produced by Phyllosticta maydis