Nordihydroguaiaretic Acid, of a New Family of Microtubule-stabilizing Agents, Shows Effects Differentiated from Paclitaxel(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
Nordihydroguaiaretic acid (NDGA) protected microtubules in NRK cells from depolymerization caused by structurally and functionally diverse drugs such as nocodazole, colchicine, vinblastine, and ilimaquinone. Hitherto reported drugs, although structurally unrelated to paclitaxel, stabilize microtubules in a way similar to that of paclitaxel and compete for paclitaxel binding to tubulin. However, NDGA had activity toward microtubules different from the effects of paclitaxel. In NRK cells, paclitaxel caused microtubule bundle formation in the presence and absence of microtubule-depolymerizing drugs. However, microtubule bundle did not form, and microtubules radiated from the microtubule-organizing center, in cells treated with NDGA. Acceleration of tubulin polymerization in vitro by paclitaxel was strong but that by NDGA was weak. Microtubules polymerized in vitro in the presence of paclitaxel, but not those polymerized in the presence of NDGA, resisted the effects of cold. NDGA seemed to bind to tubulin, but did not compete for [^3H]paclitaxel binding to tubulin. These observations indicate that NDGA belongs to a novel family of microtubule-stabilizing drugs.
- 社団法人日本農芸化学会の論文
- 2003-01-23
著者
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OSADA Hiroyuki
Antibiotics Laboratory, Discovery Research institute, RIKEN
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KONO Yoshiki
The Institute of Physical and Chemical Research
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TAKATSUKI Akira
Institute of Physical and Chemical Research(RIKEN)
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Usui Takeo
Antibiotics Laboratory Riken Discovery Research Institute
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Osada H
Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)
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Takatsuki A
Riken Saitama Jpn
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Takatsuki Akira
Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)
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NAKAMURA Machiko
Animal and Cellular Systems Laboratory
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NAKAZAWA Junko
Antibiotic Laboratory, RIKEN (Institute of Physical and Chemical Research)
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KONO Yoshiki
School of Agriculture, Ibaraki University
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Nakazawa Junko
Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)
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Kono Y
Ibaraki Univ. Ibaraki Jpn
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Kono Yoshiki
School Of Agriculture Ibaraki University
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Takatsuki Akira
Animal And Cellualr Systems Laboratory The Institute Of Physical And Chemical Research (riken)
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Usui T
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Usui Takeo
Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)
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Nakamura Machiko
Animal And Cellular Systems Laboratory:school Of Agriculture Ibaraki University
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Osada Hiroyuki
Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)
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Nakamura M
Riken Saitama Jpn
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Takatsuki A
Animal And Cellular Systems Laboratory Riken(the Institute Of Physical And Chemical Research)
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