Phosphatidylinositol-3 Kinase in Fission Yeast : A Possible Role in Stress Responses

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概要

• 論文の詳細を見る

• A DNA fragment coding for a part of a putative phosphatidylinositol 3 kinase was cloned from Schizosaccharomyces pombe by cross-hybridization with Saccharomyces cerevisiae VPS34 gene, a yeast homologue of mammalian PI-3 kinase. The clone contained an open reading frame of 797 amino acids but lacked the initiation codon, ATG. The predicted amino acid sequence was homologous to those of S. cerevisiae VPS34 and mammalian PI-3 kinase genes. Disruption of the gene resulted in extremely low levels of PI-3-P and higher levels of PI-4-P, supporting the idea that the gene codes for the PI-3 kinase of S. pombe. The disruptants harbored large vacuoles and were sensitive to stresses such as high temperature or high concentration of monovalent and divalent cations.

• 社団法人日本農芸化学会の論文
• 1995-04-23

著者

• Yoshida Minoru

  Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University School of Medicine

• HORINOUCHI Sueharu

  Department of Biotechnology, University of Tokyo

• Usui T

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Yoshida M

  Department Of Biotechnology Graduate School Of Agricultural And Life Sciences The University Of Toky

• FUKUI Yasuhisa

  Department of Applied Biological Chemistry The University of Tokyo

• Kimura Koutarou

  Department of Applied Biological Chemistry, Faculty of Agriculture and Life Science, University of T

• Miyake Sanae

  Department of Biochemistry, Faculty of Medicine, University of Toho

• Makuuchi Michiru

  Department of Applied Biological Chemistry, Faculty of Agriculture and Life Science, University of T

• Morita Rika

  Department of Applied Biological Chemistry, Faculty of Agriculture and Life Science, University of T

• Usui Takeo

  Department of Biotechnology, Faculty of Agriculture and Life Science, University of Tokyo

• Usui Takeo

  Department Of Biotechnology Faculty Of Agriculture And Life Science University Of Tokyo

• Horinouchi Sueharu

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Horinouchi Sueharu

  Dep. Of Biotechnology Graduate School Of Agriculture And Life Sciences Univ. Of Tokyo

• Fukui Y

  Research Center For Environmental Genomics Kobe University

• Morita R

  Department Of Applied Biological Chemistry Faculty Of Agriculture And Life Science University Of Tok

• Usui T

  Dep. Of Applied Biological Chemistry Fac. Of Agriculture Shizuoka Univ.

• Fukui Yuko

  Institute For Fundamental Research Suntory Ltd. (sunbor)

• Kimura Koutarou

  Department Of Agriculture And Life Science The University Of Tokyo

• Kimura Koutarou

  Department Of Applied Biological Chemistry Faculty Of Agriculture And Life Science University Of Tok

• Makuuchi Michiru

  Department Of Applied Biological Chemistry Faculty Of Agriculture And Life Science University Of Tok

• Yoshida Minoru

  Department Of Chemistry St. Marianna University School Of Medicine

• Yoshida Minoru

  Department Of Agricultural Chemistry Faculty Of Agriculture Iwate University

• Usui Takeo

  Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

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