AdpA, a Central Transcriptional Regulator in the A-Factor Regulatory Cascade That Leads to Morphological Development and Secondary Metabolism in Streptomyces griseus
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概要
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A-factor (2-isocapryloyl-3R-hydroxymethyl-γ-butyrolactone) is a microbial hormone that triggers aerial mycelium formation and secondary metabolism in Streptomyces griseus. A-factor produced in a growth-dependent manner switches on the transcription of adpA encoding a transcriptional activator by binding to the A-factor receptor protein (ArpA), which has bound the adpA promoter, and dissociating the DNA-bound ArpA from the DNA. AdpA then activates a number of genes with various functions required for morphological development and secondary metabolism, forming an AdpA regulon. AdpA, which contains a ThiJ/PfpI/DJ-1-like dimerization domain at its N-terminal portion and an AraC/XylS-type DNA-binding domain at its C-terminal portion, is a representative of a large subfamily of the AraC/XylS family. AdpA binds various positions with respect to the transcriptional start points of the target genes and recruits RNA polymerase to the specific promoter region, and facilitates the isomerization of the RNA polymerase-DNA complex into an open complex competent for transcriptional initiation. The AdpA-binding consensus sequence is 5′-TGGCSNGWWY-3′ (S: G or C; W: A or T; Y: T or C; N: any nucleotide). The DNA-binding specificity of AdpA in conjunction with that of other AraC/XylS family members is also discussed.
- 社団法人 日本農芸化学会の論文
- 2005-03-23
著者
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HORINOUCHI Sueharu
Department of Biotechnology, University of Tokyo
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OHNISHI Yasuo
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tok
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Horinouchi Sueharu
Department Of Biotechnology Graduate School Of Agricultural And Life Sciences The University Of Toky
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Horinouchi Sueharu
Department Of Agricultural Chemistry Faculty Of Agriculture University Of Tokyo
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Horinouchi Sueharu
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Horinouchi Sueharu
Dep. Of Biotechnology Graduate School Of Agriculture And Life Sciences Univ. Of Tokyo
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Ohnishi Yasuo
Department Of Biotechnology Graduate School Of Agriculture And Life Sciences University Of Tokyo
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Horinouchi S
Department Of Biotechnology The University Of Tokyo
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TOMONO Ayami
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo
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YAMAZAKI Haruka
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tok
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KATO Jun-ya
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tok
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Ohnishi Yasuo
Department Of Biotechnolog Graduate School Of Agriculture And Life Sciences The University Of Tokyo
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Tomono Ayami
Department Of Biotechnology Graduate School Of Agriculture And Life Sciences University Of Tokyo
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Yamazaki Haruka
Department Of Biotechnology Graduate School Of Agriculture And Life Sciences The University Of Tokyo
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