Evaluation of Poly(vinyl alcohol)-Gel Spheres Containing Chitosan as Dosage Form to Control Gastrointestinal Transit Time of Drugs
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概要
- 論文の詳細を見る
Two types of poly(vinyl alcohol)-gel spheres were prepared with chitosan (CS/PVA-GS) and witout chitosan (PVA-GS), and comparative studies were performed using these gel spheres (GSs). No change in particle size was observed by the addition of chitosan : nearly 45% of both particles were in the 5-10 μm range. In an in vivo gastrointestinal transit test, CS/PVA-GS prolonged the small-intestinal transit time more than PVA-GS. In an in vitro intestinal perfusion study, the mean transit time of these GSs was markedly reduced by pretreatment of the intestinal surface with a mucolytic agent, N-acetyl-L-cysteine, suggesting that the mucous layer on the intestinal surface plays an important role in controlling the transit rate of these GSs. The oral administraiton of aminophylline (theophylline) and ampicillin as model drugs incorporated in PVA-GS and CS/PVA-GS was examined in rats. While theophylline absorption from PVA-GS was not affected by the addition of chitosan, the improvement of ampicillin absorption by PVA-GS was enhanced by the chitosan combination.
- 公益社団法人日本薬学会の論文
- 1998-11-15
著者
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Yoshida Minoru
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University School of Medicine
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HIGAKI Kazutaka
Department of Basic Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyoto University
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KIMURA Toshikiro
Department of Pharmaceutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu
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Kimura Toshikiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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SUGIMOTO Katsuyoshi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University
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YATA Takashi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University
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Yata Takashi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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Higaki Kazutaka
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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Sugimoto Katsuyoshi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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Yoshida Minoru
Department Of Chemistry St. Marianna University School Of Medicine
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Yoshida Minoru
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Yoshida Minoru
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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Yoshida Minoru
Department Of Agricultural Chemistry Faculty Of Agriculture Iwate University
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Voshida Minoru
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University
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Kimura Toshikiro
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University
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