Original MRE-binding Transcriptional Factor Gene in Normal Humans is ZRF, not MTF-1
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概要
- 論文の詳細を見る
Metallothionein gene is transcriptionally regulated by heavy metals through cis-acting metal responsive elements(MREs). Two proteins, metal-regulatory transcription factor-1(MTF-1) and zinc regulatory factor(ZRF), have been isolated and cloned from human cells as MRE-binding transcriptional factor (MREBT). These proteins are almost identical to each other, except for only one base substitution at codon 185 that causes an amino acid change from histidine to tyrosine. This single amino acid difference has been reported to influence zinc-responsive transcriptional activities. In this study, we determined the nucleotide sequence of the region containing codon 185 in DNA samples obtained from normal Japanese(n=30) and three human-derived cultured cell lines. The findings indicate that all subjects have the same sequence identical to ZRF, suggesting that ZRF is the original MREBT gene in normal humans, and MTF-1 is its minor variant.
- 公益社団法人日本薬学会の論文
- 2001-12-01
著者
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Naganuma Akira
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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Matsubara Mitsunobu
Second Department Of Internal Medicine Graduate School Of Medicine Tohoku University
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Yoshida Minoru
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University School of Medicine
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Naganuma Akira
Lab. Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku Univ.
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Yoshida M
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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KITA Kayoko
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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MIURA NOBUHIKO
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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Kita Kayoko
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
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Miura N
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
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Miura Nobuhiko
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
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Yoshida M
Tokyo Univ. Sci. Tokyo Jpn
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Imai Yutaka
Laboratory of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, To
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Imai Y
Laboratory Of Clinical Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Toho
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Naganuma Akira
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Science Tohoku
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Yoshida Minoru
Department Of Chemistry St. Marianna University School Of Medicine
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Yoshida Minoru
Department Of Agricultural Chemistry Faculty Of Agriculture Iwate University
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