Characterization of antioxidant protection of cultured neural progenitor cells (NPC) against methylmercury (MeHg) toxicity
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概要
- 論文の詳細を見る
Methylmercury (MeHg) is an environmental pollutant known to cause neurobehavioral defects and is especially toxic to the developing brain. With recent studies showing that fetal exposure to low-dose MeHg causes developmental abnormalities, it is therefore important to find ways to combat its effects as well as to clarify the mechanism(s) underlying MeHg toxicity. In the present study, the effects of MeHg on cultured neural progenitor cells (NPC) derived from mouse embryonic brain were investigated. We first confirmed the vulnerability of embryonic NPC to MeHg toxicity, NPC from the telencephalon were more sensitive to MeHg compared to those from the diencephalon. Buthionine sulfoximine (BSO) which is known to inhibit glutathione synthesis accelerated MeHg toxicity. Furthermore, antioxidants such as N-acetyl cysteine and α-tocopherol dramatically rescued the NPC from MeHg's toxic effects. Interestingly, a 12hr delay in the addition of either antioxidant was still able to prevent the cells from undergoing cell death. Although it is now difficult to avoid MeHg exposure from our environment and contaminated foods, taking anti-oxidants from foods or supplements may prevent or diminish the toxicological effects of MeHg.
- 2009-06-01
著者
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Naganuma Akira
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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WATANABE Jun
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Shioda S
Department Of First Anatomy Showa University School Of Medicine
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Shioda Seiji
Department Of Anatomy Showa University School Of Medicine
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Shioda Seiji
昭和大学藤が丘病院 循環器内科
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Shioda Seiji
昭和大学 薬学部
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Nakamachi Tomoya
Department Of First Anatomy Showa University School Of Medicine
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Nakamachi Tomoya
昭和大学藤が丘病院 循環器内科
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Nakamachi Tomoya
Department Of Anatomy Showa University School Of Medicine
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NAKAMURA Masahisa
Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University
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Ogawa Tetsuo
Anti-aging Funded Research Labs School Of Medicine Showa University
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Shioda Seiji
Department Of Anatomy School Of Medicine Showa University
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Nakajo Sigeo
Department of Anatomy, School of Medicine, Showa University
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Nakajo Sigeo
Department Of Anatomy School Of Medicine Showa University:laboratory Of Biochemistry Yokohama Colleg
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Shioda Seiji
Laboratory Of Regulatory Biology Graduate School Of Science And Engineering University Of Toyama
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Nakamura Masahisa
Department Of Biology Faculty Of Education And Integrated Arts And Sciences Waseda University
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Nakamura Masahisa
Department Of Biology Faculty If Education And Integrated Arts And Sciences Waseda University
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Shioda Seiji
昭和大学 医学部第一解剖学教室
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Shiota Seiji
Department Of Anatomy Showa University School Of Medicine
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Naganuma Akira
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Science Tohoku
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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Naganuma Akira
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
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Watanabe Jun
Department Of Anatomy School Of Medicine Showa University:department Of Biology Faculty Of Education
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Shioda Seiji
Department Of Anatomy Showa University School Of Medicine Tokyo Japan
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