THE EXISTENCE OF MULTI-ENDOCRINE CELLULAR ANTIGEN (MECA) IN THE ACTH-PRODUCING CELLS OF THE GERBIL ADENOHYPOPHYSIS : CONFOCAL LASER SCANNING MICROSCOPIC ANALYSIS

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概要

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• We had serendipitously discovered a novel protein, which has cross-immunoreactivity the antibody SCBAX-PI. This immunoreactive substance was designated as multi-endocrine cellular antigen (MECA), because it was present in the hypothalamus, neuro- and adenohypophysis, thyroid and parathyroid glands, and pancreatic islets. In this study, to determine what type of cells contains MECA, we analyzed the adenohypophysis of the gerbil with the confocal laser scanninng microscopy, after double-immunofluorescence staining using ACTH-, GH-, FSH/LH-, Prolactin- or TSH-antibody. In consequence, MECA-containing cells completely corresponded to the ACTH -producing cells in the gerbil and rat. It was also revealed that MECA was found only one cell-group in each endocrine gland. These findings suggest that MECA is closely correlated with "cell-differentiation" as its function. Therefore, further investigation will be applied to the research field on regeneration medicine.

• 日本組織細胞化学会の論文

著者

• WATANABE Jun

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Tanaka Yuetsu

  Ryukyu Univ.

• Tamada Yoshitaka

  大阪歯科大学 解剖学

• Tamada Y

  Department Of Anatomy Osaka Dental University

• Tamada Yoshitaka

  大阪歯科大学 解剖学-組織学

• YAMADA Hisao

  Department of Anatomy and Cell Science, Kansai Medical University

• Yamada Hisao

  Department Of Anatomy And Cell Science Kansai Medical University

• KATAOKA Yosky

  Department of Anatomy and Cell Science, Kansai Medical University

• TAKAMORI Yasuharu

  Department of Anatomy and Cell Science, Kansai Medical University

• Nihira Mika

  Department of Anatomy and Cell Science, Kansai Medical University

• Utsunomiya Kazuhiro

  Department of Anatomy and Cell Science, Kansai Medical University

• Takamidoh Shoichiroh

  Department of Anatomy and Cell Science, Kansai Medical University

• Tamura Yasuhisa

  Department Of Anatomy And Cell Science Kansai Medical University

• Hisa Y

  Otolaryngology-head And Neck Surgery Graduate School Of Medical Science Kyoto Prefectural University

• Tamada Yoshitaka

  Dept.of Anatomy And Neurobiology Kyoto Prefectural Univ.of Medicine

• Watanabe Junichi

  Aska Pharmaceutical Co. Ltd. Research & Development Division

• Yamada H

  Department Of Anatomy And Cell Science Kansai Medical University

• Nihira Mika

  Department Of Anatomy And Cell Science Kansai Medical University

• Kataoka Y

  Department Of Anatomy And Cell Science Kansai Medical University

• Watanabe Jun

  Department Of Anatomy & Cell Science Kansai Medical University

• Hamada Yoshinori

  Department Of Anatomy And Cell Science Kansai Medical University

• Yamada Hisao

  Department Of Anatomy And Cell Science Kmu 21c Coe Project Kansai Medical University

• Takamidoh Shoichiroh

  Third Department Of Internal Medicine Kansai Medical University

• Yamada Hisao

  Department Of Anatomy And Cell Biology Shiga University Of Medical Science

• Utsunomiya Kazuhiro

  Department Of Anatomy And Cell Science Kansai Medical University

• Utsunomiya K

  Department Of Anatomy And Cell Science Kansai Medical University

• Takamori Yasuharu

  Department Of Anatomy And Cell Science Kansai Medical University

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