Poor Prognosis of Japanese Patients With Chronic Heart Failure Following Myocardial Infarction : Comparison With Nonischemic Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
Background Myocardial infarction (MI) is one of the- major etiologies of chronic heart failure (CHF) in Japan. Methods and Results The prognoses of CHF patients after MI (n=283) were investigated by comparing them with those of CHF patients with nonischemic cardiomyopathy (NICM, n=310) from the CHF registry (CHART; n=1,154). The Kaplan-Meier (KM) analyses revealed that the 3-year all-cause mortality was significantly higher in the MI cohort compared with the NICM cohort (29.0% vs 12.4%, p<0.0005). Age/gender/treatment-adjusted KM analysis revealed significant differences only in the cohorts with preserved left ventricular ejection fraction (LVEF), defined as LVEF >45%, or in less symptomatic patients (New York Heart Association I or II). Multi-variate Cox regression analysis showed that /?-blocker (BB) was associated with a significant reduction in mortality from cardiac causes, and either angiotensin-converting enzyme inhibitor or angiotensin receptor blocker (ACEI/ARB) was significantly related to the improvement of survival in the MI cohort (adjusted hazard ratio: 0.222 and 0.497, p<0.05), even though these medicines were used significantly less often in the MI cohort. Conclusions Underlying MI has a significant impact on the survival of Japanese CHF patients, especially those with preserved LVEF or with fewer symptoms. The appropriate expansion of ACEI/ARB or BB therapy might be necessary to improve their survival.
- 社団法人日本循環器学会の論文
- 2005-01-20
著者
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KAGAYA Yutaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Kagaya Yutaka
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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小岩 喜郎
Oizumi Memorial Hospital
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WATANABE Jun
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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SHINOZAKI Tsuyoshi
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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SHIBA Nobuyuki
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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SAKUMA Masahito
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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SHIRATO Kunio
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Koseki Yoshito
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Takahashi Chiaki
東北大学 医学部量子診断学
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Soma Masayoshi
Division Of Nephrology Hypertension And Endocrinology Department Of Medicine Nihon University School
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Soma Masayoshi
日本大学 医学部内科学系腎臓高血圧内分泌内科
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Koiwa Yoshiro
東北大学 循環器内科
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Koiwa Yoshiro
東北文化学園大学 医療福祉
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Koiwa Y
Department Of Electronic Engineering Graduate School Of Engineering Tohoku University
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Watanabe Jun
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Soma Masayoshi
Division Of General Medicine Department Of Medicine Nihon University School Of Medicine
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Takahashi Shoki
Department Of Radiology Tohoku University Graduate School Of Medicine
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Shirato Kunio
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Shinozaki Tsuyoshi
Department Of Cardiovascular Medicine Sendai Medical Center
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Shiba Nobuyuki
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Koiwa Yoshiro
Graduate School Of Medicine Tohoku University
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Sakuma Masahito
Department Of Cardiovascular Medicine
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Sakuma Masahiko
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Koiwa Yoshio
1st Dept. Of Intern. Med. Tohoku Univ.
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Suzuki Takashi
Department Of Radiology Tohoku University Graduate School Of Medicine
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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Shiba Nobuyuki
Departments Of Cardiovascular Medicine And Evidence-based Cardiovascular Medicine Tohoku University
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Shiba Nobuyuki
Departments Of Cardiovascular Medicine And Evidence-based Cardiovascular Medicine Tohoku University
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Sugi Masafumi
女川町立病院 内科
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Shiba Nobuyuki
Departments Of Cardiovascular Medicine And Evidence-based Cardiovascular Medicine Tohoku University
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Sonoda Masahiro
Second Department Of Cardiology National Hospital Organization Kagoshima Medical Center
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Koseki Yoshito
Medical Information Center Tohoku University Hospital
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Shiba Nobuyuki
Department of Cardiology, International University of Health and Welfare Hospital
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