Portopulmonary Hypertension : Hemodynamics, Pulmonary Angiography, and Configuration of the Heart

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Background The goal of the present study was to examine the cardiac configuration and pulmonary vascular changes in patients with portopulmonary hypertension (PPHTN) and compare them with those of idiopathic pulmonary arterial hypertension (IPAH). Methods and Results The subjects were 10 patients with PPHTN and 18 with IPAH. In PPHTN, the increases in the right ventricular end-diastolic volume index (89±19 vs 128±50ml/m^2; p=0.04), right end-systolic volume index (50±19 vs 95±47ml/m^2; p=0.02) and right ventricular mass index (47±18g/m^2 vs 79±31; p=0.04) were low compared with IPAH. The decrease in the right ventricular ejection fraction was also low in PPHTN (45±10 vs 28±13%; p=0.01). The degree of sparse arborization and abrupt narrowing on wedged pulmonary angiography was moderate in PPHTN compared with IPAH. In PPHTN, the proximal pulmonary arteries were dilated near the segmental arteries, which were narrow in IPAH. Conclusion Changes in the configuration of the heart were moderate in PPHTN compared with those in IPAH. The degree of sparse arborization and abrupt narrowing were also moderate in PPHTN.
社団法人日本循環器学会の論文
2005-10-20