Effect of Nifekalant, a Class III Anti-Arrhythmic Agent, on Ca^<2+> Waves in Rat Intact Trabeculae
スポンサーリンク
概要
- 論文の詳細を見る
Background Nifekalant, a class III anti-arrhythmic agent, has been used clinically at serum concentrations of 1-10μmol/L in patients with ventricular arrhythmias. However, the effect of nifekalant on triggered arrhythmias has not yet been established. Methods and Results Trabeculae were dissected from the right ventricles of 16 rat hearts. The force was measured using a silicon strain gauge, the membrane potential using ultra-compliant microelectrodes, and the regional intracellular Ca^<2+>([Ca^<2+>]_i) using electrophoretically microinjected fura-2 and an image intensified CCD camera at a sarcomere length of 2.1μm. Rapid cooling contractures (RCCs) were measured to estimate the Ca^<2+> content in the sarcoplasmic reticulum. Ca^<2+> waves and aftercontractions were measured after the induction of reproducible Ca^<2+> waves. Nifekalant at 1, 10 and 250μmol/L increased significantly the action potential duration, the peak [Ca^<2+>]_i, the developed force and the amplitude of RCCs in a concentration-dependent manner (stimulus interval=2s, [Ca^<2+>]_o=0.7mmol/L, 26.0±0.2℃). Nifekalant at 10 and 250μmol/L increased significantly the velocity of Ca^<2+> waves with an enhancement of the aftercontractions (stimulus interval=0.5s for 7.5s, [Ca^<2+>]_o=1.8±0.1 mmol/L, 22.3±0.5℃). Conclusions Nifekalant, even at a therapeutic concentration, can increase muscle contraction, but may worsen triggered arrhythmias because of the acceleration of Ca^<2+> waves under Ca^<2+>-overloaded conditions.
- 社団法人日本循環器学会の論文
- 2005-05-20
著者
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KAGAYA Yutaka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Kagaya Yutaka
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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WATANABE Jun
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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SHIRATO Kunio
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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ENDO Hideaki
Department of Marine Science, Tokyo University of Marine Science and Technology (TUMST)
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Watanabe Jun
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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HIROSE Masanori
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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WAKAYAMA Yuji
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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SUGAI YOSHINAO
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Miura Masahito
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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DMY Bruno
Department of Medicine, University of Calgary
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EDJ Henk
Department of Medicine, University of Calgary
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Shirato Kunio
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Dmy Bruno
Cardiovascular Research Group Faculty Of Medicine The University Of Calgary
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Endo Hideaki
Department Of Cardiology Tohoku University
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Miura Masahito
Tohoku University School Of Health Science
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Wakayama Yuji
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Hirose Masanori
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicin
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Miura Masahito
The First Department Of Internal Medicine Tohoku University School Of Medicine
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Miura Masaetsu
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Wakayama Yuji
Department Of Cardiology Graduate School Of Medicine Tohoku University
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Sugai Yoshinao
Department Of Cardiology Tohoku University
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Watanabe J
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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Miura Masahito
Department Of Cardiology Tohoku University
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Matsuzaki Masunori
Departments Of Cardiovascular Medicine And Evidence-based Cardiovascular Medicine Tohoku University
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Miura Masaetsu
Department Of Internal Medicine Furukawa City Hospital
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Miura Masahito
Department Of Clinical Physiology Health Science Tohoku University Graduate School Of Medicine
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Matsuzaki Masunori
Departments Of Cardiovascular Medicine And Evidence-based Cardiovascular Medicine Tohoku University
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Hirose Masanori
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicinee
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Miura Masanobu
Departments Of Cardiovascular Medicine And Evidence-based Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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