Uptake of Fractionated Heparin by Two Types of Scavenger Receptors in Isolated Rat Kupffer Cells

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概要

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• The uptake of fractionated heparin was examined in the absence and presence of anionic proteins such as acetylated low density lipoprotein (Ac-LDL) and maleylated bovine serum albumin (Mal-BSA) to characterize the scavenger receptors involved in the uptake of fractionated heparin in isolated rat Kupffer cells. The uptake of fractionated heparin was completely inhibited by Ac-LDL and dextran sulfate, but only partially by Mal-BSA.Kinetic analysis revealed that the binding capacity (B_<max>) of the Mal-BSA-insensitive receptor was significantly larger than that of the Mal-BSA-sensitive one, though their dissociation constants (K_d) were not significantly different. The apparent internalization rate constant (k_<int, app>) was significantly larger for the Mal-BSA-sensitive receptor than for the Mal-BSA-insensitive one. Thus, the scavenger receptors involved in the uptake of fractionated heparin in Kupffer cells can be classified into two types, in terms of sensitivity to Mal-BSA. Mal-BSA-sensitive receptors have been characterized in macrophages and classified as class A. The Mal-BSA-sensitive one found in Kupffer cells in this study may belong to class A, while the Mal-BSA-insensitive one has been little characterized elsewhere.

• 社団法人日本薬学会の論文
• 2000-06-01

著者

• NAKAMURA Takatoshi

  Department of Neurosurgery, Asahikawa Red Cross Hospital

• WATANABE Jun

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Noda Takashi

  国立循環器病センター 心臓血管内科

• Nakajima T

  National Center For Child Health And Dev. Tokyo Jpn

• Nakajima Toshiharu

  国立医薬品食品衛生研究所

• 林 弥生

  College Of Pharmacy Kinjo Gakuin University

• Watanabe J

  School Of Pharmacy Aichi Gakuin University

• YUASA HIROAKI

  Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University

• Nakamura T

  Department Of Allergy And Immunology National Research Institute For Child Health And Development Na

• Yuasa Hiroaki

  Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Nagoya City University

• Watanabe J

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Hayashi Y

  Life Science Laboratories Central Research Laboratories Ajinomoto Co. Inc.:pharmaceuticals Research

• Watanabe Jun

  Department Of Anatomy & Cell Science Kansai Medical University

• Hayashi Yayoi

  Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University

• Nakamura Takatoshi

  Department Of Neurosurgery Asahikawa Red Cross Hospital

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