Changes in the Density of Cytochrome P-450 2B1/2 Molecules in the Membrane of Endoplasmic Reticulum in Perivenular, Midzonal and Periportal Hepatocytes of Rats after Administration of Phenobarbital
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概要
- 論文の詳細を見る
To examine the relationship between induction of phenobarbital (PB)-inducible cytochrome P-450 (P-450) 2B1/2 and the PB-induced proliferation of endoplasmic reticulum (ER) in hepatocytes, we measured the amount of P-450 2B1/2, amount of total P-450 isoforms, and area of ER in the cytoplasm of perivenular, midzonal and periportal hepatocytes from adult male rats injected with 80 mg/kg of PB once a day for 3 days by quantitative immunohistochemistry. microphotometry and morphometry, respectively. Then. the density of P-450 2B1/2 or total P-450 molecules in the ER membrane (number of molecules per μm^2 of ER) was calculated by dividing P-450 2B1/2 or total P-450 content by the ER area followed by multiplying Avogadro's number. P-450 2B1/2 content in hepatocyte cytoplasm increased markedly in perivenular (15 times). midzonal (20 times) and periportal hepatocytes (10 times) after PB injection. The area of ER increased all hepatocytes(1.7-1.9 times) after PB injection. Thus the density of P-450 2B1/2 in the ER membrane increased markedly in hepatocytes in the three zones. whereas that of total P-450 increased slightly. The proportion of P-450 2B1/2 density to total P-450 density in the ER membrane increased markedly in perivenular hepatocytes and moderately in midzonal and periportal hepatocytes after PB injection. Thus P-450 2B1/2 molecules in the ER membrane increased in perivenular hepatocytes with reduction in molecules of other P-450 isoforms after PB injection (substitutional increase). whereas the value increased in midzonal and periportal hepatocytes without reduction in other P-450 isoforms (additive increase).
- 日本組織細胞化学会の論文
著者
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WATANABE Jun
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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Watanabe J
Department Of Anatomy & Cell Science Kansai Medical University
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TAKAMORI Yasuharu
Department of Anatomy and Cell Science, Kansai Medical University
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Mondo Hiroko
Department of Anatomy and Cell Science, Kansai Medical University
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Tamura Yasuhisa
Department Of Anatomy And Cell Science Kansai Medical University
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TAKEDA Kazuo
Department of Medicine, Kyoto Prefectural University of Medicine
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Watanabe Junichi
Aska Pharmaceutical Co. Ltd. Research & Development Division
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Takeda Koichi
Department Of Pathology Wakayama Medical University
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Kanamura Shinsuke
Department of Anatomy, Kansai Medical University
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Kanamura Shinsuke
Department Of Anatomy Kansai Medical University
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Mondo Hiroko
Department Of Anatomy And Cell Science Kansai Medical University
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Watanabe Jun
Department Of Pathology School Of Medicine Kitasato University
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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Tabuse Katsuyoshi
Department Of Surgery National Hospital Organization Osaka Minami Medical Center
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Kanamura S
Kansai Medical Univ.
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Takeda Kazuo
Department Of Biology School Of Medicine University Of Occupational And Environmental Health
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Takamori Yasuharu
Department Of Anatomy Kansai Medical University
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Takamori Yasuharu
Department Of Anatomy And Cell Science Kansai Medical University
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