Pharmacokinetic/Pharmacodynamic Relationship of Eptazocine, a Narcotic-Antagonist Analgesic, in Rats

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概要

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• The relstionship between the pharmacokinetics and the pharmacodynamics of eptazocine, a narcotic-antagonist analgesic, was investigated in rats. The analgesic effect of eptazocine (2.5,5 and 10 mg/kg) following intravenous (i.v) administration was evaluated by both the Randall-Selitto method and the D'Amour-Smith method. The analgesic effects were determined before and at designed intervals for a period of 120 min after eptazocine administration, and are expressed as area under the effect-time curve (AUC_E). The plasma concentration of eptazocine was determined by fluorescence HPLC and was analyzed with a two compartment open model using the nonlinear least-squares method. Eptazocine produced a dose-dependent analgesic effect. It was demonstrated that eptazocine has a linear relationship between AUC_E and the area under the plasma concentration-time curve (AUC) following i.v. administration for three different doses ranging from 2.5 to 10 mg/kg.

• 公益社団法人日本薬学会の論文
• 2000-12-01

著者

• WATANABE Jun

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

• Watanabe J

  School Of Pharmacy Aichi Gakuin University

• Shimizu Ryosuke

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Hanano Manabu

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Tokyo

• SUZUKI Toyofumi

  Department of Pharmaceutics, College of Pharmacy, Nihon University

• TOMONO Kazuo

  Department of Pharmaceutics, College of Pharmacy, Nihon University

• Tomono K

  Res. Unit Of Pharmaceutics Coll. Of Pharmacy Nihon Univ.

• Tomono K

  Nihon Univ. Chiba Jpn

• Tomono Kazuo

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Hanano Manabu

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Hanano M

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Hanano M

  Department Of Pharmaceutical Science College Of Pharmacy Nihon University

• Shimizu R

  (pressent Address)biomedical Research Institue Hab Discussion Group

• Hanano M

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Hanano Manabu

  Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:department

• Suganuma Taiyo

  (pressent Address)department Of Pharmacology Tokyo Women's Medical University

• Watanabe J

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• SHIMIZU Ryo

  (Pressent address)Biomedical Research Institue, HAB Discussion Group

• NISHINO Jun-ichi

  (Pressent address)Drug Regulatory Affairs Department, Navartis Pharma K.K.,

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Nishino Junichi

  (pressent Address)drug Regulatory Affairs Department Navartis Pharma K.k.

• Watanabe Jun

  Department Of Anatomy & Cell Science Kansai Medical University

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