Isolation and Identification of Acetyl-CoA Carboxylase Inhibitors from Green Tea (Camellia sinensis)
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概要
- 論文の詳細を見る
An aqueous methanol extreact from green tea showed potent acetyl-CoA carboxylase inhibitory activity.An active compound was isolated from the extract and identified as (-)-epigallocatechin gallate by instrumental analyses. The IC_50 value of (-)-epigallocatechin gallate was 3.1×10^<-4>M.Among tea catechins and related compounds, nearly equal activity was found in (-)-epigallocatechin gallate and (-)-epicatechin gallate, whereas (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, gallic acid and methyl gallate each had no inhibitory activity.These results indicate that the 3-O-gallate group of the catechin structure was necessary for this activity.(-)-Epigallocatechin gallate inhibited triglyceride accumulation in 3T3-L1 cells at a concentration of 1.0×10^<-7>M or higher.
- 社団法人日本農芸化学会の論文
- 1998-03-23
著者
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WATANABE Jun
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
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KAWABATA Jun
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
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Kawabata J
Hokkaido Univ. Sapporo Jpn
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Kawabata Jun
Graduate School Of Agriculture Hokkaido University
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Kawabata Jun
Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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Kawabata Jun
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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NIKI Ryoya
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
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Kawabata Jun
Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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Niki R
Institute Of Dairy Science Faculty Of Agriculture Hokkaido University
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Niki Ryoya
Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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Niki Ryoya
Research Center Yotsuba Milk Products Co. Ltd.
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Watanabe J
Food Function Division National Food Research Institute
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Watanabe Jun
Department Of Anatomy & Cell Science Kansai Medical University
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