Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae

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概要

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• We searched a yeast genomic library for genes that conferred methylmercury resistance to yeast. Ymr258c was identified as a factor that conferred strong methylmercury resistance when overexpressed in budding yeast. Ymr258c is regarded as one of the F-box proteins, i.e., component factors of the Skp 1/Cullin/F-box protein (SCF) complex that functions as a ubiquitin ligase in the ubiquitin-proteasome system. In this study, Ymr258c was demonstrated to function as an F-box protein to reduce methylmercury toxicity. The overexpression of Ymr258c might promote the ubiquitination of proteins that are involved in the enhancement of methylmercury toxicity, and thereby promote their degradation by proteasomes to reduce methylmercury toxicity.

• 日本トキシコロジー学会の論文
• 2009-08-01

著者

• Naganuma Akira

  Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho

• WADA Naomi

  Laboratory of System Physiology, Veterinary Medical School, Yamaguchi University

• Kuge Shusuke

  Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku

• Kuge Shusuke

  東北大学 薬研究 生体防御薬

• Wada Naomi

  Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku

• HWANG Gi-Wook

  Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho

• Hwang Gi-wook

  Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku

• Naganuma A

  Tohoku Univ. Sendai Jpn

• Naganuma Akira

  Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Science Tohoku

• Naganuma Akira

  Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku

• Naganuma Akira

  Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ

• Hwang Gi-wook

  Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku

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