Role of Intracellular Defense Factors against Methylmercury Toxicity
スポンサーリンク
概要
- 論文の詳細を見る
Methylmercury (MeHg) is a causative agent of Minamata disease and an environmental pollutant that comprises a large portion of organically occurring mercury. Many aspects of the biological defense mechanisms against MeHg toxicity remain unclear. Recently, nuclear factor-E2-related factor 2 (Nrf2), heat shock factor protein 1 (Hsf1), and hydrogen sulfide were identified as intracellular defense factors against MeHg toxicity. These findings suggest that novel biological defense mechanisms against MeHg toxicity exist in the living organism. In addition, the expression of downstream genes that mediate activation of the transcription factors Nrf2 and Hsf1 was markedly induced by MeHg treatment, suggesting that this action is involved in the reduction of MeHg toxicity. On the other hand, when the gaseous form of hydrogen sulfide (H2S) binds directly to MeHg, bismethylmercury sulfide (MeHg-S-HgMe) as a low toxicity metabolite is formed. This suggests the involvement of the gaseous form of H2S in the reduction of MeHg toxicity. In this topic, we summarize the roles of factors involved in novel biological defense mechanisms against MeHg toxicity.
著者
-
Hwang Gi-wook
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
-
HWANG Gi-Wook
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
関連論文
- siRNA-mediated AMPKα1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells
- Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae
- siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells
- Investigation of Intracellular Factors Involved in Methylmercury Toxicity
- DNA microarray analysis of transcriptional responses of human neuroblastoma IMR-32 cells to methylmercury
- Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS) in budding yeast(Toxicogenomics/proteomics Report)
- siRNA-mediated knockdown of the melanocortin 2 receptor accessory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK293 cells
- Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells
- Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae
- Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae(Toxicogenomics/proteomics Report)
- Role of the Ubiquitin-proteasome System in Methylmercury Toxicity in Saccharomyces cerevisiae
- A ubiquitin-proteasome system as a determination factor involved in methylmercury toxicity(Molecular Mechanism for Toxicity of Metals, Proceedings of the 32nd Annual Meeting)
- Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury
- Characterization of Surface Properties, Osteoblast Cell Culture in Vitro and Processing with Flow-Viscosity of Ni-Free Ti-Based Bulk Metallic Glass for Biomaterials
- siRNA-mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells
- A screening for essential cell growth-related genes involved in arsenite toxicity in Saccharomyces cerevisiae
- Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae
- Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells
- Role of Intracellular Defense Factors against Methylmercury Toxicity
- Increased production of reactive oxygen species by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells
- Methylmercury induces CCL2 expression through activation of NF-κB in human 1321N1 astrocytes
- Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice
- Ubiquitin-conjugating enzyme Cdc34 mediates methylmercury resistance in Saccharomyces cerevisiae by increasing Whi2 degradation
- Identification of deubiquitinating enzymes involved in methylmercury toxicity in Saccharomyces cerevisiae
- Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS) in budding yeast
- Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury