Role of the Ubiquitin-proteasome System in Methylmercury Toxicity in Saccharomyces cerevisiae
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概要
- 論文の詳細を見る
Methylmercury (MeHg) is an important environmental pollutant that causes severe disorders of the central nervous system, but the mechanism underlying its toxicity and the corresponding biological defense mechanisms remain largely unknown. Saccharomyces cerevisiae (S. cererisiae) yeast cells were used to elucidate the defense mechanisms against MeHg toxicity and to search for novel genes involved in MeHg resistance. S. cerevisiae is a eukaryotic organism that possesses many gene products that are functionally similar to those of mammals such as humans. We have previously reported that Cdc34 and Rad23 confer MeHg resistance to yeast cells. Interestingly, the both proteins are related to ubiquitin-proteasome system (UP system) that is involved in the intracellular degradation of proteins. In our detailed experiments, we found that the UP system might play an important role in lending protection against MeHg toxicity. This review summarizes the results of our studies on the role of the UP system as a defense mechanism against MeHg toxicity in yeast cells.
著者
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HWANG Gi-Wook
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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Hwang Gi-wook
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
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Hwang Gi-Wook
Laboratory of Molecular and Biochemical Toxicology, Graduate of Pharmaceutical Sciences, Tohoku University
関連論文
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- DNA microarray analysis of transcriptional responses of human neuroblastoma IMR-32 cells to methylmercury
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- Role of the Ubiquitin-proteasome System in Methylmercury Toxicity in Saccharomyces cerevisiae
- A ubiquitin-proteasome system as a determination factor involved in methylmercury toxicity(Molecular Mechanism for Toxicity of Metals, Proceedings of the 32nd Annual Meeting)
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