Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury
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概要
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To elucidate the molecular mechanism involved in methylmercury-induced cerebellar disorder, we performed DNA microarray analysis of the cerebellum of methylmercury-treated mice. The expression levels of 21 genes were elevated 2-fold or higher in response to methylmercury, including many genes encoding proteins involved in inflammatory reactions associated with chemokines. The expression levels of 11 genes were reduced by half or more in response to methylmercury.
- 日本トキシコロジー学会の論文
著者
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Takahashi Tsutomu
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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Naganuma Akira
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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HWANG Gi-Wook
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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Lee Jin-Yong
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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RYOKE Katsunori
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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Matsuyama Fujio
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences,Tohok
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Kim Jong-Mu
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences,Tohok
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- Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury