siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells
スポンサーリンク
概要
- 論文の詳細を見る
We performed functional gene screening, using a siRNA library targeting 8, 500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells.
- 日本トキシコロジー学会の論文
- 2007-12-14
著者
-
Takahashi Tsutomu
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
-
Naganuma Akira
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
-
Kuge Shusuke
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
-
Kuge Shusuke
東北大学 薬研究 生体防御薬
-
HWANG Gi-Wook
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
-
KITA Kayoko
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
-
HAYASHI Tatsuya
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
-
Hwang Gi-wook
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
-
Naganuma A
Tohoku Univ. Sendai Jpn
-
Kita Kayoko
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
-
Naganuma Akira
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Science Tohoku
-
Takahashi Tsutomu
Laboratory Of Kampo-pharmaceutics Faculty Of Pharmacy Osaka Ohtani University
-
Naganuma Akira
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
-
Hayashi Tatsuya
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
-
Naganuma Akira
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
-
Hwang Gi-wook
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
-
Takahashi Tsutomu
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
-
Takahashi Tsutomu
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
関連論文
- Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast
- Characterization of antioxidant protection of cultured neural progenitor cells (NPC) against methylmercury (MeHg) toxicity
- Fibrinolytic activity of ligustilide and pharmaceutical comparison of Angelica acutiloba roots before and after processing in hot water
- Quality of Angelica acutiloba roots cultivated and processed in Sichuan province of China
- siRNA-mediated AMPKα1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells
- HeLa Cell Transformants Overproducing Mouse Metallothionein Show in vivo Resistance to cis-Platinum in Nude Mice
- Role of Metallothionein in Protection against Renal Oxidative Stress Induced by cis-Diamminedichloroplatinum (II) in Glutathione-Depleted Mice
- Applications of HeLa Cells with High Catalase Activity in Toxicological Investigations (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Metallothionein as a Possible Antidote for Oxidative Injury
- W2-3 Metallothionein as a Possible Antidote for Oxidative Injury
- Optimum Schedule of Selenium Administration to Reduce Lethal and Renal Toxicities of cis-Diamminedichloroplatinum in Mice
- Dietary Selenium Has a Protective Potency against Fetolethal Toxicity of Methylmercury
- PROTECTION OF SIDE EFFECTS OF ANTICANCER DRUGS BY PRETREATMENT WITH BISMUTH COMPOUNDS
- TOXICOKINETICS OF SODIUM SELENITE IN PREGNANT MICE
- EFFECT OF SELENITE ON RENAL TOXICITY AND ANTITUMOR ACTIVITY OF CIS-DIAMMINEDICHLOROPLATINUM IN MICE INOCULATED WITH EHRLICH ASCITES TUMOR CELL
- INORGANIC MERCURY FORMATION FROM METHYLMERCURY BY ORGANS OF MOUSE, IN VITRO
- EFFECTS OF SODIUM SELENITE ON DISTRIBUTION AND PLACENTAL TRANSFER OF MERCURIC MERCURY IN MICE OF LATE GESTATIONAL PERIOD
- Role of metallothionein as a protective factor against radiation carcinogenesis
- Protective role of metallothionein in bone marrow injury caused by X-irradiation
- DNA microarray analysis of transcriptional responses of yeast cells to expression of core protein of hepatitis C virus
- Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae
- siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells
- Investigation of Intracellular Factors Involved in Methylmercury Toxicity
- High-fat diet reduces the stimulatory effects of a single bout of exercise on glucose transport and insulin sensitivity in rat skeletal muscle
- siRNA-mediated knockdown of the melanocortin 2 receptor accessory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK293 cells
- Three New Saponins as Index Compounds of Glycyrrhiza flavescens BOISS. Growing in Turkey
- Characterization of an immortalized hepatic stellate cell line established from metallothionein-null mice
- DNA microarray analysis of transcriptional responses of human neuroblastoma IMR-32 cells to methylmercury
- Endogenous Factors Involved in Enterohepatic Circulation of Methylmercury with Special Reference to Its Chemical Form (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Effect of Selenium on Biliary Excretion of Methylmercury (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- A SIMPLE AND RAPID METHOD FOR PREPARATION OF ^HgLABELED METHYLMERCURY FROM ^HgCl_2 AND METHYLCOBALAMIN
- Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS) in budding yeast(Toxicogenomics/proteomics Report)
- siRNA-mediated knockdown of the melanocortin 2 receptor accessory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK293 cells
- Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells
- Original MRE-binding Transcriptional Factor Gene in Normal Humans is ZRF, not MTF-1
- Caffeine can activate 5'AMP-activated protein kinase and increase insulin-independent glucose uptake in rat skeletal muscles
- Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae
- Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae(Toxicogenomics/proteomics Report)
- Enhancement of paraquat toxicity by glutathione depletion in mice in vivo and in vitro
- Effect of Glutathione Depletion on Metallothionein Synthesis Induced by Paraquat in Mice
- Role of the Ubiquitin-proteasome System in Methylmercury Toxicity in Saccharomyces cerevisiae
- Cisplatin-induced expression of iron-retaining genes FIT2 and FIT3 in Saccharomyces cerevisiae
- A ubiquitin-proteasome system as a determination factor involved in methylmercury toxicity(Molecular Mechanism for Toxicity of Metals, Proceedings of the 32nd Annual Meeting)
- Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury
- Effect of Zinc Deficiency on the Behavior of Metallothionein-I, II Knockout Mice
- Optimum Conditions for Derivatization of Glutathione, Cysteine and Cysteinylglycine in Human Plasma with Ammonium 7-Fluorobenzo-2-Oxa-1,3-Diazole-4-Sulfonate for Accurate Quantitation by High-Performance Liquid Chromatography
- Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury
- Effect of aldehyde dehydrogenase-2 genotype on cardiac autonomic nervous responses to moderate alcohol ingestion
- Human Exposure to Mercury and the Accumulation of Methylmercury that is Associated with Gold Mining in the Amazon Basin, Brazil
- Three New Saponins as Index Compounds of Glycyrrhiza flavescens BOISS. Growing in Turkey
- Characterization of Surface Properties, Osteoblast Cell Culture in Vitro and Processing with Flow-Viscosity of Ni-Free Ti-Based Bulk Metallic Glass for Biomaterials
- siRNA-mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells
- A screening for essential cell growth-related genes involved in arsenite toxicity in Saccharomyces cerevisiae
- Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae
- Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells
- Biological interaction of dietary metals (WORKSHOP2: EFFECTS OF FOODS ON DRUG EFFECTS) (Proceedings of the 30th Annual Meeting)
- Role of Intracellular Defense Factors against Methylmercury Toxicity
- Increased production of reactive oxygen species by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells
- Methylmercury induces CCL2 expression through activation of NF-κB in human 1321N1 astrocytes
- Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice
- Ubiquitin-conjugating enzyme Cdc34 mediates methylmercury resistance in Saccharomyces cerevisiae by increasing Whi2 degradation
- Identification of deubiquitinating enzymes involved in methylmercury toxicity in Saccharomyces cerevisiae
- Increased dystrophin mRNA and protein levels in atrophic skeletal muscles in streptozotocin-induced diabetic rats
- Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS) in budding yeast
- Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury