Protective role of metallothionein in bone marrow injury caused by X-irradiation
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概要
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In order to elucidate the role of metallothionein (MT) in preventing the adverse effects of X-ray irradiation, we examined the susceptibility of MT-I/II null mice to bone marrow injury caused by X-irradiation and effects of pretreatment with MT-inducing metals on X-ray injury. Eight-week-old male mice were exposed to a single bout of whole-body X-irradiation at a dose between 0.1 and 6.0Gy. The numbers of leukocytes, reticulocytes with micronuclei (MNRET) in the blood, and polychromatic erythrocytes with micronuclei (MNPCE) in the bone marrow were determined 24hr after X-irradiation. X-irradiation significantly decreased the total number of leukocytes in MT-I/II null mice and wild-type mice in a dose-dependent manner, but the total number of leukocytes was significantly lower in MT-I/II null mice than in wild-type mice at a low dose of irradiation, between 0.1 and 1.0Gy. X-irradiation (0.1 and 0.5Gy) significantly increased the appearance of MNRET and MNPCE in both strains, but the increase was greater in the MT-I/II null mice than in the wild-type mice. Additional groups of mice were pre-administered bismuth nitrate or zinc sulfate to induce MT in the bone marrow cells prior to X-irradiation; the X-ray injury was prevented by such treatments in wild-type mice only. Thus, the present results suggest that MT plays a protective role against a low dose of X-ray injury.
- 2008-10-01
著者
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Naganuma Akira
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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SATOH Masahiko
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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KITO Hideaki
Gifu Pharmaceutical University
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SUZUKI Junko
Research Center for Environmental Risk, National Institute for Environmental Studies
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Kito Hideaki
Graduate School Of Education Hyogo University Of Teacher Education
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Kito Hideaki
岐阜薬科大学 公衆衛
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SEO Makoto
Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University
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Kito Hideaki
Department Of Public Health Gifu Pharmaceutical University
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Seo Makoto
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Suzuki Junko
Research Center For Environmental Risk National Institute For Environmental Studies
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Satoh Masahiko
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Shibuya Kiyoshi
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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Tohyama Chiharu
Division of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Grad
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Shibuya Kiyoshi
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
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Tohyama Chiharu
Division Of Environmental Health Sciences Center For Disease Biology And Integrative Medicine Gradua
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Tohyama Chiharu
Environmental Health Sciences Division National Institute For Environmental Studies:department Of Hy
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Tohyama Chiharu
Environmental Health Sciences Division National Institute For Environmental Studies:center For Disea
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Naganuma A
Tohoku Univ. Sendai Jpn
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Kito Hideaki
Department Of Hygienics Gifu Pharmaceutical University
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Tohyama C
Environmental Health Sciences Division National Institute For Environmental Studies:center For Disea
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Mishima Satoshi
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Naganuma Akira
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Science Tohoku
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Satoh Masahiko
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Kurita Hisaka
Department Of Hygienics. Gifu Pharmaceutical University
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Naganuma Akira
Laboratory Of Molecular And Biochemical Toxicology Graduate School Of Pharmaceutical Sciences Tohoku
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Naganuma Akira
Department Of Public Health And Molecular Toxicology School Of Pharmaceutical Sciences Kitasato Univ
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Sato Motoyasu
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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