Involvement of metallothionein (MT) as a biological protective factor against carcinogenesis induced by benzo[a]pyrene (B[a]P)
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概要
- 論文の詳細を見る
The purpose of this study was to examine whether intracellular metallothionein (MT) protects against benzo[a]pyrene (B[a]P)-induced forestomach and lung carcinogenesis. Ten-week-old male MT-I/II null mice and wild-type mice were orally administered B[a]P at a dose of 100 or 250 mg/kg twice a week for 4 weeks. B[a]P-induced mortality was higher in the MT-I/II null mice than in the wild-type mice. The incidence of tumors in the forestomach and lung was 78.6% and 7.1% in the wild-type mice treated with 100 mg/kg B[a]P, respectively. In the MT-I/II null mice treated with B[a]P, tumor incidence in the forestomach and lung was 100% and 33.3%, respectively. The tumor area in the forestomach and lung in the MT-I/II null mice treated with B[a]P was greater than that of wild-type mice. These results suggest that MT acts as a biological protective factor against carcinogenesis induced by B[a]P.
- 日本トキシコロジー学会の論文
- 2010-04-01
著者
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SATOH Masahiko
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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Nagase H
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Nagase Hisamitsu
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Nagase Hisamitsu
岐阜薬科大学 公衆衛
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NAGASE Hisamitsu
Dept.Public Health, Gifu Pharmaceutical University
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TAKAISHI Masaki
Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University
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SHIMADA Akinori
Department of Veterinary Pathology, Tottori University
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SUZUKI Junko
Research Center for Environmental Risk, National Institute for Environmental Studies
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Shimada Akinori
Dep. Of Veterinary Pathology Fac. Of Agriculture Tottori Univ.
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Takaishi Masaki
岐阜薬科大学 衛生学
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Takaishi Masaki
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Nagase Hisamitsu
Lab. Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical Univ.
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Seo Makoto
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Suzuki Junko
Research Center For Environmental Risk National Institute For Environmental Studies
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Satoh Masahiko
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Satoh Masahiko
Department Of Hygienics Gifu Pharmaceutical University
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Shimada Akinori
Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University
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Nakane Hideo
Laboratory Of Viral Oncology Aichi Cancer Center Research Institute
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Sakamoto Maya
Department Of Oral Diagnosis And Radiology Tohoku University Graduate School Of Dentistry
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Satoh Masahiko
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Sato Motoyasu
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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