Predictable Increase of Central Nervous System Stimulation by a Pyrolysis Product in Smoking Dimethylamphetamine

概要

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We carried out a dimethylamphetamine (DMA) smoking experiment that is closer to some real cases. In this study, we heated DMA hydrochloride (DMA-HC1) in the range of about 250℃ to 350℃, in which demethylation reaction occurred mainly, with a smoke collection apparatus and gas lighter, and trapped the generating vapor with an adsorption cartridge. The eluate desorbed from the cartridge and residual materials inside the smoke collection apparatus were analyzed by gas chromatography-mass spectrometry and liquid chromatography-electrospray ionization-mass spectrometry. Methamphetamine (MA) and amphetamine (AM) were produced via demethylation from the dimethylamino group of DMA. Allylbenzene (AB), benzaldehyde (BA), cis-β-methylstyrene (cMS), benzyl chloride (BC) and trans-β-methylstyrene (tMS) in addition to MA and AM, were also formed as pyrolysis products. The molar percentages of a pyrolyzate MA and AM to the starting DMA were 21.4 and 1.8%, respectively, and the total molar percentage of AB, BA, cMS, BC and tMS was 2.9%. Taking into account the central nervous system stimulation by DMA and MA in humans, the total stimulant effects of the drugs that are ingested in a body can be calculatedly increased more than fourfold by smoking DMA. The present data show that a DMA smoking abuser may be able to get a more powerful stimulant effect by smoking than by injecting.
社団法人日本薬学会の論文
2004-06-01