Suppressive Effect of Aspirin on Chromosome Aberration Induced by Mitomycin C in Mice

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Chromosome aberrations induced by mitomycin C(MMC)were suppressed by aspirin in a mouse micronucleus test with peripheral blood and bone marrow cells. Aspirin at doses of 0.5, 5, and 50mg/kg was injected intraperitoneally or per administered orally 0.5, 6. or 24 h after administration of MMC and then peripheral blood and/or bone marrow cells were sampled 48 h after administration of MMC. The suppressive effect of aspirin was more pronounced in the aspirin-treated groups 24 h than 0.5 and 6 h after administration of MMC. In the aspirin-treated group at 24 h, the frequency of polychromatic erythrocytes with micronuclei was decreased by about 60-80% after intraperitoneal injection and by about 40-70% after oral administration. It is suggested that aspirin may directly act on MMC metabolites, but not on MMC itself.
公益社団法人日本薬学会の論文
2001-08-01