Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity
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概要
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We examined the sensitivity of metallothionein (MT)-III null mice to cadmium (Cd)-induced acute hepatotoxicity. MT-I/II null mice were also used to compare Cd toxicities between MT-III null mice and MT-I/II null mice. Male MT-I/II null mice, MT-III null mice and wild-type mice were given s.c. injection of Cd (5-20 µmol/kg) and then the blood and liver were collected from each mouse under ether anesthesia at 2 days after the administration. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities elevated by injection of Cd were significantly higher in the MT-I/II null mice than in the wild-type mice. In the MT-III null mice, ALT and AST activities were not elevated following the injection of Cd. Further, marked morphological changes such as necrosis of hepatocytes, severe hemorrhage and congestion were observed by injection of Cd in both MT-I/II null mice and wild-type mice, whereas the degree of injury was found to be more extensive in MT-I/II null mice. In contrast, only occasional damage was observed in the liver of MT-III null mice treated with the same dose of Cd. These morphological observations were consistent with the results of ALT and AST activities. In the present study, it was clearly found that MT-III null mice were resistant to Cd hepatotoxicity, although MT-I/II null mice were sensitive to its toxicity. MT-III may be an accelerative factor in Cd-induced acute hepatotoxicity.
- 日本トキシコロジー学会の論文
- 2010-04-01
著者
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FUJIWARA Yasuyuki
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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SATOH Masahiko
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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Nagase H
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Nagase Hisamitsu
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Nagase Hisamitsu
岐阜薬科大学 公衆衛
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HONDA Akiko
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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NAGASE Hisamitsu
Dept.Public Health, Gifu Pharmaceutical University
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KOMURO Hiroaki
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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HOZUMI Isao
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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INUZUKA Takashi
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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HARA Hideaki
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University
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SHIMADA Akinori
Department of Veterinary Pathology, Tottori University
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HASEGAWA Tatsuya
Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences
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SEKO Yoshiyuki
Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences
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Shimada Akinori
Dep. Of Veterinary Pathology Fac. Of Agriculture Tottori Univ.
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Seko Yoshiyuki
徳島文理大学 薬学部衛生化学
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Seko Yoshiyuki
Dep. Of Environmental Biochemistry Yamanashi Inst. Of Environmental Sciences
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Seko Yoshiyuki
Department Of Environmental Biochemistry Yamanashi Institute Of Environmental Sciences
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Inuzuka Takashi
岐阜大学 医学系研究科神経内学老年学
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Inuzuka Takashi
Department Of Neurology And Geriatrics Gifu University Graduate School Of Medicine
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Hozumi Isao
岐阜大学 医学系研究科神経内学老年学
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Hozumi Isao
Dep. Of Neurology And Geriatrics Gifu Univ. Graduate School Of Medicine
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Hozumi Isao
Department Of Neurology And Geriatrics Gifu University Graduate School Of Medicine
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Fujiwara Yasuyuki
北陸大学 薬学部環境健康学
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Fujiwara Yasuyuki
Lab. Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin Univ.
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Hara Hideaki
Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University
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Inuzuka Takashi
Department Of Geriatrics And Neurology School Of Medicine Gifu University
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Seo Makoto
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Honda Akiko
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Honda Akiko
Laboratory For Exercise Physiology And Biomechanics School Of Health And Sport Sciences Chukyo Unive
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Komuro Hiroaki
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Satoh Masahiko
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Fujiwara Yasuyuki
Dep. Of Environmental Health Fac. Of Pharmaceutical Sciences Hokuriku Univ.
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Fujiwara Yasuyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences
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Satoh Masahiko
Lab. Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin Univ.
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Satoh Masahiko
Department Of Hygienics Gifu Pharmaceutical University
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Shimada Akinori
Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University
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Hasegawa Tatsuya
Department Of Environmental Biochemistry Yamanashi Institute Of Environmental Sciences
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Sakamoto Maya
Department Of Oral Diagnosis And Radiology Tohoku University Graduate School Of Dentistry
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Satoh Masahiko
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Fujiwara Yasuyuki
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Sato Motoyasu
Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University
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Hasegawa Tatsuya
Dep. Of Environmental Biochemistry Yamanashi Inst. Of Environmental Sciences
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