The Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis
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概要
- 論文の詳細を見る
Atherosclerosis is a vascular lesion that is a common health problem in advanced countries. Functional damage of the vascular endothelial cells, vascular smooth muscle cell hyperplasia, and procoagulant/antifibrinolytic state of blood are generally observed in the lesion. Since polysaccharides such as heparin modulate vascular cell behavior through interaction with cytokines/growth factors, we hypothesized that polysaccharides from natural sources may possess beneficial biological activities that prevent atherosclerosis. Changes in cultured aortic endothelial and smooth muscle cells were investigated after treatment with the polysaccharides sodium spirulan(Na-SP) - a sulfated polysaccharide obtained from a hot water extract of the blue-green alga Spirulina platensis - and colominic acid (CA)-prepared as a homopolymer of N-acetylneuraminic acid produced by Escherichia coli K1. The experiments suggest that depolymerized Na-SP and sulfated CA can function as precursors of the agents that prevent atherosclerosis. In particular, both the chemically modified polysaccharides significantly inhibit the proliferation of the arterial smooth muscle cells without exhibiting any toxic effects on the integrity of the vascular endothelial cell layers. The results also indicate that chemical modifications, for example, depolymerization of Na-SP and sulfation of CA, can control the biological effects of these polysaccharides on vascular cells.
- 社団法人日本薬学会の論文
- 2006-06-01
著者
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FUJIWARA Yasuyuki
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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Fujiwara Yasuyuki
北陸大学 薬学部環境健康学
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Fujiwara Yasuyuki
Lab. Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin Univ.
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Kaji T
Organization For Frontier Research In Preventive Pharmaceutical Sciences Hokuriku University
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Kaji Toshiyuki
Organization For Frontier Res. In Preventive Pharmaceutical Sciences Hokuriku Univ.
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Kaji Toshiyuki
Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamamoto Chika
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
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Fujiwara Yasuyuki
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
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Kaji Toshiyuki
Department Of Environmental Sciences Faculty Of Pharmaceutical Sciences Hokuriku University
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Kaji Toshiyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences:organization For Frontier Rese
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Kaji Toshiyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamamoto C
Organization For Frontier Research In Preventive Pharmaceutical Sciences Hokuriku University
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Yamamoto Chika
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Hokuriku University
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Fujiwara Yasuyuki
Dep. Of Environmental Health Fac. Of Pharmaceutical Sciences Hokuriku Univ.
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Fujiwara Yasuyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences
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Fujiwara Yasuyuki
Department Of Cardiovascular Surgery Seijunkai Johoku Hospital
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Kaji T
北陸大学薬学部:北陸大学学術フロンティア研究組織
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Yamamoto Chika
Organization Of Frontier Research For Preventive Pharmaceutical Science Hokuriku University:departme
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