Regulation of Proteoglycan Synthesis in Vascular Endothelial Cells by Transforming Growh Factor-β_1 Is Cell Density-Dependent
スポンサーリンク
概要
- 論文の詳細を見る
Proteoglycans (PGs) synthesized y vascular endothelial cells contribute to the formation of the vascular extracellular matrix and also influence cellular proliferation and migration ; however, the regulation of the synthesis is not completely understood. It has been shown that endothelial PG synthesis is regulated by growth factors and cytokines such as transforming growth factor-β (TGF-β), interleukin-1β and tumor necrosis factor-α, and changes under physiological, pathological, pathological and therpeutic conditions. TGF-β_1 is cytokine that regulates PG synthesis in various cell types including vascular endothelial and smooth muscle cells, and the regulation has been implicated in the pathogenesis of atherosclerosis in the vascular tissue. It has been shown that TGF-β_1 directs different patterns of PG synthesis in endothelial cells at different cell densities. TGF-β_1 promotes the synthesis of both perlecan and biglycan when endothelial cell density is high whereas only biglycan synthesis is stimulated when the cell density is low. Furthermore, glycosaminoglycan chains occur as elongated forms only biglycans that are synthesized by the cells growing at high density. This density-dependent regulation of PG synthesis by TGF-β_1 may be unique to the endothelial cell, and may play a role in the regulation of endothelial cell functions by growth factors and cytokines, which are involved in the pathogenesis of atherosclerosis.
- 日本結合組織学会の論文
- 2001-03-25
著者
-
Kaji Toshiyuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Hokuriku University
-
KAJI TOSHIYUKI
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
関連論文
- Arsenite but not arsenate inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells
- Homocysteine Inhibits Proteoglycan Synthesis in Cultured Bovine Aortic Smooth Muscle Cells
- The Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis
- Proteoglycans Predominantly Synthesized by Human Brain Microvascular Endothelial Cells in Culture are Perlecan and Biglycan
- Selective Promotion of Plasminogen Activator Inhibitor-1 Secretion by Activation of Proteinase-Activated Receptor-1 in Cultured Human Brain Microvascular Pericytes : Comparison with Endothelial Cells(Biochemistry/Molecular Biology)
- Proteoglycans Released from Cultured Bovine Aortic Endothelial Cell Layers by Sodium Spirulan Are Both Perlecan and Biglycan(Biochemistry/Molecular Biology)
- Stimulation of Proteoglycan Release from Cultured Vascular Endothelial Cell Layers by Sodium Spirulan
- Characterization of Chondroitin/Dermatan Sulfate Proteoglycans Synthesized by Bovine Retinal Pericytes in Culture(Highlighted paper selected by Editor-in-chief)(Biochemistry/Molecular Biology)
- Analysis of Chondroitin/Dermatan Sulfate Microstructure in Cultured Vascular Smooth Muscle Cells after Exposure to Lead and Cadmium
- Vascular Smooth Muscle Cells in Culture Express Tumor Necrosis Factor-α That Suppresses Collagen Synthesis Depending on Cell Density
- Effects of Tumor Necrosis Factor-α on the Synthesis of DNA, the Secretion of Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases, and the Activity of Invasive Migration in Cultured Vascular Smooth Muscle Cells
- Inhibition of the Association of Proteoglycans with Cultured Vascular Endothelial Cell Layers by Calcium and Sodium Spirulan
- REGULATION OF BIGLYCAN AND DECORIN SYNTHESIS BY CONNECTIVE TISSUE GROWTH FACTOR IN CULTURED BOVINE AORTIC ENDOTHELIAL CELLS
- Selective Increase in Decorin Core mRNA Level in Cultured Vascular Smooth Muscle Cells after Exposure to Advanced Glycation Endproducts
- Effect of Lead on the Synthesis of Tissue Plasminogen Activator by Vascular Endothelial Cells in Culture
- An Organobismuth Compound that Exhibits Selective Cytotoxicity to Vascular Endothelial Cells in Vitro
- Perspectives on Cadmium Toxicity Research
- Mechanism of Cadmium Stimulation on the Production of Fibrinolytic Proteins in Vascular Endothelial Cells (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Characterization of an immortalized hepatic stellate cell line established from metallothionein-null mice
- Inhibition of Cultured Bovine Aortic Smooth Muscle Cell Proliferation by Colominic Acid(Pharmacology)
- Differential Effects of Sodium Spirulan on the Secretion of Fibrinolytic Proteins from Vascular Endothelial Cells : Enhancement of Plasminogen Activator Activity
- Atherosclerosis and Extracellular Matrix
- Induction of Plasminogen Activator Inhibitor Type 1 Synthesis by Cadmium in Human Vascular Endothelial Cells in Culture
- Proteoglycan Synthesis is Not Influenced by Zinc in Proliferating Bovine Aortic Endothelial Cells in Culture
- Disaccharide Composition of Glycosaminoglycan Chains in Growing Vascular Endothelial Cells in Culture after Exposure to Lead
- Inhibitory Effect of Rhodamine B on the Production of Glycosaminoglycans by Cultured Human Lip Fibroblasts
- Inhibitory but Reversible Effect of Rhodamine B on the Proliferation of Cultured Human Lip Fibroblasts
- Effects of Zinc on the Proliferation of Cultured Vascular Endothelial Cells and Vascular Smooth-Muscle Cells (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Interaction between Cadmium and Zinc on Cell Damage and Its Possible Mechanisms (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Cadmium-Induced Alteration of Glycosaminoglycans in Cultured Vascular Endothelial Cells (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Stimulatory Effect of Cadmium on the Release of Plasminogen Activator Inhibitor-1 from Cultured Human Vascular Endothelial Cells (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Inhibitory Effect of Lead on the Release of Tissue Plasminogen Activator from Human Vascular Endothelial Cells in Culture (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Protective Effect of Zinc against Cadmium Toxicity on Cultured Vascular Endothelial Cells and Its Mechanism (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Decrease in the Number of Cultured Vascular Endothelial Cells by Cadmium
- DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium
- Protective effect of pretreatment with cilostazol on cytotoxicity of cadmium and arsenite in cultured vascular endothelial cells
- Suppression of Proteoglycan Synthesis by Calcium lonophore A23187 in Cultured Vascular Endothelial Cells : Implication of Intracellular Calcium Accumulation in Lead Inhibition of Endothelial Proteoglycan Synthesis
- SII-04 Molecular Mechanisms for Cadmium and Lead Toxicity in Vascular Tissue
- Mechanism of Lead Inhibition of Vascular Endothelial Cell Proliferation(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Sodium Arsenite Inhibits Proteoglycan Synthesis by Vascular Endothelial Cells in Culture
- Inhibition of the Repair of Injured Endothelial Cell Monolayers by Lead and Its Possible Mechanisms
- Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells
- Cellular Defense Mechanisms against Lead Toxicity in the Vascular System
- Regulation of Proteoglycan Synthesis in Vascular Endothelial Cells by Transforming Growh Factor-β_1 Is Cell Density-Dependent
- A convenient method to assess chemical modification of protein thiols by electrophilic metals