血管内皮細胞のプロテオグリカン代謝の制御を介した外来性糖鎖の活性(誌上シンポジウム)
スポンサーリンク
概要
- 論文の詳細を見る
Proteoglycan contains glycosmainoglycans, which are endogenous sulfated polysaccharides, in the molecule. The metabolism of proteoglycans regulates cell behavior and cellular events. It is possible that exogenous polysaccharide-related molecules exhibit their biological activities by two mechanisms. One is the interaction with cells and the other is the interaction with growth factors/cytokines that regulate proteoglycans. In this review, we describe sodium spirulan, a sulfated polysaccharide obtained from a hot-water extract of the blue-green alga Spirulina platensis, as an exogenous polysaccharide that stimulates the release of proteoglycans from vascular endothelial cells. Factors that regulate endothelial proteoglycan metabolism are also being described as possible target molecules of exogenous polysaccharides. Further research is required to obtain exogenous polysaccharide-related molecules that exhibit useful biological activities through controlling endothelial proteoglycan metabolism for protection against vascular lesions such as atheroslcerosis.
- 2008-05-01
著者
-
鍛冶 利幸
北陸大学 薬学部 境健康学教室
-
鍛冶 利幸
北陸大学 薬学部
-
鍛冶 利幸
北陸大学薬学部環境科学教室
-
山本 千夏
北陸大学薬学部環境科学教室
-
山本 千夏
北陸大学薬学部
-
藤原 泰之
北陸大学 薬学部
-
鍜冶 利幸
北陸大学 薬学部
-
鍜治 利幸
北陸大・薬
-
鍛治 利幸
北陸大学薬学部環境健康学
-
Yamamoto Chika
Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University
-
佐藤 友子
北陸大学薬学部
-
藤原 泰之
北陸大学薬学部
-
Kaji T
北陸大学薬学部:北陸大学学術フロンティア研究組織
-
Yamamoto C
北陸大学薬学部:北陸大学学術フロンティア研究組織
-
鍛冶 利幸
北陸大学薬学部
関連論文
- 周生期脳障害における神経幹細胞を用いた新規治療法の基礎研究
- Stimulants from Gardeniae Fructus for Cultured Endothelial Cell Proliferation
- Cadmium Stimulation of Glycosaminoglycan Synthesis by Cultured Vascular Endothelial Cells : Comparison of Various Cell Types
- Resistance of human brain microvascular endothelial cells in culture to methylmercury : cell-density-dependent defense mechanisms
- 血管内皮細胞のプロテオグリカン代謝の制御を介した外来性糖鎖の活性(誌上シンポジウム)
- A3 トロンビンレセプターが介在する血管内皮細胞プロテオグリカン合成の調節
- Suppression of fibroblast growth factor-2 expression : Possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells
- Arsenite but not arsenate inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells
- Homocysteine Inhibits Proteoglycan Synthesis in Cultured Bovine Aortic Smooth Muscle Cells
- Methylmercury Retards the Repair of Wounded Monolayer of Human Brain Microvascular Endothelial Cells by Inhibiting Their Proliferation without Nonspecific Cell Damage
- The Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis
- Proteoglycans Predominantly Synthesized by Human Brain Microvascular Endothelial Cells in Culture are Perlecan and Biglycan
- Selective Promotion of Plasminogen Activator Inhibitor-1 Secretion by Activation of Proteinase-Activated Receptor-1 in Cultured Human Brain Microvascular Pericytes : Comparison with Endothelial Cells(Biochemistry/Molecular Biology)
- Proteoglycans Released from Cultured Bovine Aortic Endothelial Cell Layers by Sodium Spirulan Are Both Perlecan and Biglycan(Biochemistry/Molecular Biology)
- Stimulation of Proteoglycan Release from Cultured Vascular Endothelial Cell Layers by Sodium Spirulan
- Characterization of Chondroitin/Dermatan Sulfate Proteoglycans Synthesized by Bovine Retinal Pericytes in Culture(Highlighted paper selected by Editor-in-chief)(Biochemistry/Molecular Biology)
- Analysis of Chondroitin/Dermatan Sulfate Microstructure in Cultured Vascular Smooth Muscle Cells after Exposure to Lead and Cadmium
- Induction of versican V0 variant synthesis by activation of protease-activated receptor-1 in vascular smooth muscle cells
- Vascular Smooth Muscle Cells in Culture Express Tumor Necrosis Factor-α That Suppresses Collagen Synthesis Depending on Cell Density
- Effects of Tumor Necrosis Factor-α on the Synthesis of DNA, the Secretion of Matrix Metalloproteinases/Tissue Inhibitors of Metalloproteinases, and the Activity of Invasive Migration in Cultured Vascular Smooth Muscle Cells
- Inhibition of the Association of Proteoglycans with Cultured Vascular Endothelial Cell Layers by Calcium and Sodium Spirulan
- REGULATION OF BIGLYCAN AND DECORIN SYNTHESIS BY CONNECTIVE TISSUE GROWTH FACTOR IN CULTURED BOVINE AORTIC ENDOTHELIAL CELLS
- Selective Increase in Decorin Core mRNA Level in Cultured Vascular Smooth Muscle Cells after Exposure to Advanced Glycation Endproducts
- Induction of Decorin Core Protein Synthesis by Advanced Glycation Endproducts in Cultured Vascular Smooth Muscle Cells(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Remodeling of Vascular Endothelial Glycocalyx by Basic Fibroblast Growth Factor (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- 動脈硬化進展の鍵分子プロテオグリカン : その特性及び合成調節(誌上シンポジウム)
- 鉛による血管内皮細胞の増殖阻害とその機序について
- F-6 血管内皮細胞層からのプロテオグリカン放出に対する新奇硫酸化多糖ナトリウムスピルランの促進作用
- B-18 TGF-βによる増殖期血管内皮細胞のプロテオグリカン産生の制御
- Vascular Smooth Muscle Cells in Culture Are Highly Sensitive to Cadmium Cytotoxicity without Species-Related Differences : Comparison with Chang Liver Cells
- Induction of Metallothionein by Thrombin in Cultured Vascular Endothelial and Smooth Muscle Cells
- Stimulation of Cultured Vascular Smooth Muscle Cell Proliferation by Thrombospondin Is Potentiated by Zinc
- アディポネクチンによる血管平滑筋細胞デコリン合成の誘導
- Characterization of Tumor Necrosis Factor Alpha-Induced Alteration of Glycosaminoglycans in Cultured Cells : Comparison among Vascular Smooth-Muscle Cells, Vascular Endothelial Cells, Chang Liver Cells and LLC-PK1 Cells
- 低用量カドミウム曝露と健康影響 : (2)生活習慣病と生殖毒性
- Effects of Cadmium and Lead on the Release of Fibrinolytic Proteins from Vascular Endothelial Cells, Vascular Smooth Muscle Cells and Fibroblasts (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Correlation between the Physicochemical Property of Some Nonsteroidal Anti-inflammatory Drugs and Changes in Adenosine Triphosphate, Glutathione and Hemoglobin in Rat Erythrocytes(Biopharmacy)
- カドミウムの毒性の新しい文献情報の調査研究 カドミウムの毒性に関する文献調査研究 (平成12年度 カドミウムの健康影響に関する研究)
- カドミウムの毒性の新しい文献情報の調査研究 カドミウムの毒性に関する文献調査研究 (カドミウムの健康影響に関する研究)
- A8 ウシ網膜周皮細胞が産生するプロテオグリカンの特性
- 線溶調節を行う血管細胞に対するカドミウム及び鉛の毒性発現に関する研究
- Effects of Aspirin and/or Salicylate on Hydrolysis and Glucuronidation of Indomethacin in Rat Erythrocytes and Hepatocytes
- A11 ヒト脳微小血管内皮および周皮細胞が産生するプロテオグリカンの特性(第36回日本結合組織学会学術大会)
- A Novel Transmetallation of Triarylstibanes into Arylboronate : Boro-induced Ipso-deantimonation and Its Theoretical Calculation
- An Organobismuth Compound that Exhibits Selective Cytotoxicity to Vascular Endothelial Cells in Vitro
- プロテインキナーゼCの活性調節に細胞膜貫通型プロテオグリカンが関与する
- Mechanism of Cadmium Stimulation on the Production of Fibrinolytic Proteins in Vascular Endothelial Cells (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- 重金属の血管毒性に関する細胞生物学的研究
- Modulation by Endothelin-1 of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Release from Cultured Human Vascular Endothelial Cells : Interaction of Endothelin-1 with Cytokines
- Low Molecular Weight Heparin Enhances Prostacyclin Production by Cultured Human Endothelial Cells
- Inhibition of Cultured Bovine Aortic Smooth Muscle Cell Proliferation by Colominic Acid(Pharmacology)
- Differential Effects of Sodium Spirulan on the Secretion of Fibrinolytic Proteins from Vascular Endothelial Cells : Enhancement of Plasminogen Activator Activity
- Proteoglycan Synthesis is Not Influenced by Zinc in Proliferating Bovine Aortic Endothelial Cells in Culture
- Disaccharide Composition of Glycosaminoglycan Chains in Growing Vascular Endothelial Cells in Culture after Exposure to Lead
- Inhibitory but Reversible Effect of Rhodamine B on the Proliferation of Cultured Human Lip Fibroblasts
- Alteration of Heparan Sulfate Proteoglycans Induced by Cadmium and Lead in Cultured Vascular Endothelial Cells (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Effects of Zinc on the Proliferation of Cultured Vascular Endothelial Cells and Vascular Smooth-Muscle Cells (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Interaction between Cadmium and Zinc on Cell Damage and Its Possible Mechanisms (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Effect of Lead on the Proliferation of Cultured Vascular Endothelial Cells and Vascular Smooth-Muscle Cells (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Effects of Cadmium on the Regulation of Blood Fibrinolysis by Vascular Endothelial Cells, Vascular Smooth-Muscle Cells and Fibroblasts (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Cadmium-Induced Alteration of Glycosaminoglycans in Cultured Vascular Endothelial Cells (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Stimulatory Effect of Cadmium on the Release of Plasminogen Activator Inhibitor-1 from Cultured Human Vascular Endothelial Cells (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Inhibitory Effect of Lead on the Release of Tissue Plasminogen Activator from Human Vascular Endothelial Cells in Culture (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Protective Effect of Zinc against Cadmium Toxicity on Cultured Vascular Endothelial Cells and Its Mechanism (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Decrease in the Number of Cultured Vascular Endothelial Cells by Cadmium
- DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium
- Protective effect of pretreatment with cilostazol on cytotoxicity of cadmium and arsenite in cultured vascular endothelial cells
- 低用量カドミウム曝露と健康影響 : (2)生活習慣病と生殖毒性
- 培養血管内皮細胞層の修復に対する亜鉛と鉛の相互作用
- 培養血管内皮細胞におけるグリコサミノグリカン合成とその硫酸化に対するカドミウムと亜鉛の相互作用
- 培養血管内皮細胞層の修復に対する亜鉛の促進作用
- メタロチオネインを誘導しない濃度の亜鉛によるカドミウムの細胞毒性の軽減
- 緑膿菌の巧妙な戦略
- Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells