Effects of Aspirin and/or Salicylate on Hydrolysis and Glucuronidation of Indomethacin in Rat Erythrocytes and Hepatocytes
スポンサーリンク
概要
- 論文の詳細を見る
This study was conducted to explore the mechanism of the pharmacokinetic interaction between aspirin (ASP) and indomethacin (IND) using rat erythrocytes (RBCs) and hepatocytes. ASP was hydrolyzed to salicylic acid (SA) in both the RBCs and hepatocytes. Within RBCs, aspirin and/or salicylate (ASP/SA) increased the concentration of IND, accompanied by a constant hydrolysis of IND. In hepatocytes, a low dose of IND was subjected to glucuronidation rather than hydrolysis, and ASP/SA inhibited both the acylglucuronidation of IND and hydrolysis of IND glucuronide. A high dose of IND underwent hydrolysis with about double the glucuronidation, and ASP/SA decreased the ratio of hydrolysis to glucuronidation, accompanied by a loss of ASP, IND and their metabolites from the medium. Collectively, the results provide metabolic insight into the mechanism of drugdrug interaction between ASP/SA and IND in the hepatocytes and RBCs.
- 公益社団法人日本薬学会の論文
- 2003-05-01
著者
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松本 宜明
日本大学薬学部臨床薬物動態学ユニット
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鈴木 和美
Showa College of Pharmaceutical Sciences
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SHIMIZU Makiko
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
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MATSUMOTO Yoshiaki
Department of Clinical Pharmacology and Toxicology, Showa College of Pharmaceutical Sciences
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Suzuki Kazutoshi
放射線医学総合研究所分子イメージング研究センター
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Matsumoto Y
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Suzuki K
Pharmaceutical Frontier Research Laboratories Japan Tobacco Inc.
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Fujii M
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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Fujii Makiko
Department Of Pharmaceutics Showa College Of Pharmaceutical Science
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Yamamoto Chika
Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University
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Suzuki Kenji
Suntory Institute For Biomedical Research Wakayamadai
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Suzuki K
Noda Research Laboratories Drug Delivery System Institute Ltd.:(present Address)pharmaceutics Resear
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Kato Shingo
Research Center Hospital For Charged Particle Therapy National Institute Of Radiological Sciences
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SHIMIZU Makiko
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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MATSUSHITA Reiko
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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YAMAMOTO Chizuru
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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TSUYUKI Aki
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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SUZUKI Kayoko
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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Shimizu Makiko
Showa Pharmaceutical University
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Shimizu M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Shimizu Makiko
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
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Shimizu Makiko
Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University
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Shimizu Makiko
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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TSUYUKKI Aki
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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OHYA Kumiko
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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FUKUOKA Msamichi
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Suzuki Kazutoshi
Department Of Medical Imaging National Institute Of Radiological Sciences
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Suzuki Kazutoshi
Clinical Neuroimaging Section Department Of Molecular Neuroimaging Molecular Imaging Center National
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Matsumoto Yoshiaki
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Division Of Medical Chemistry National Institute Of Hygienic Sciences
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Matsumoto Yoshiaki
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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松本 宣明
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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Suzuki K
Molecular Imaging Center National Institute Of Radiological Sciences
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Tsuyukki Aki
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Ohya Kumiko
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Suzuki Kayoko
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University:(present Office)mitsu
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Yamamoto C
北陸大学薬学部:北陸大学学術フロンティア研究組織
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Saito Miwako
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
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Matsumoto Yoshiaki
Department Of Clinical Pharmacokinetics College Of Pharmacy Nihon University
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