Testicular Toxicity of Mono-n-Butyl Phthalate and Related Phthalates on Bound Iron in Rat Red Blood Cells
スポンサーリンク
概要
- 論文の詳細を見る
It was previously reported that free iron was released from rat red blood cells in both an in vitro study with a metabolite, mono-n-butylphthalate (MBP), of di-n-butylphthalate (DBP) and an in vivo study with oral DBP, inducing rat testicular atrophy in hypoxic conditions due to MBP-induced hemoglobin deprivation. This study investigated whether mono-n-alkylphthalates (alkyl-carbon C_4-C_6 ; MAP), which result in rat testicular damage, induce iron release from hemoglobin by incubation with rat red blood cells. Iron release was observed with C_3-C_6 MAP incubation at lower doses and with C_1 and C_2 MAP incubation at higher doses, but not with C_7, C_8, and C_4(6) MAP.
- 公益社団法人日本薬学会の論文
- 2002-12-01
著者
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松本 宜明
日本大学薬学部臨床薬物動態学ユニット
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SHIMIZU Makiko
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
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MATSUMOTO Yoshiaki
Department of Clinical Pharmacology and Toxicology, Showa College of Pharmaceutical Sciences
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FUKUOKA Masamichi
Department of Clinical Pharmacology and Toxicology, Showa College of Pharmaceutical Sciences
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Matsumoto Y
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Watanabe Nobuo
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Sci
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Fujii M
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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Fujii Makiko
Department Of Pharmaceutics Showa College Of Pharmaceutical Science
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Watanabe N
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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SHIMIZU Makiko
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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Shimizu Makiko
Showa Pharmaceutical University
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Shimizu M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Shimizu Makiko
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
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Shimizu Makiko
Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University
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Shimizu Makiko
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Matsumoto Yoshiaki
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Division Of Medical Chemistry National Institute Of Hygienic Sciences
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Matsumoto Yoshiaki
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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松本 宣明
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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Fukuoka M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Saito Miwako
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
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Matsumoto Yoshiaki
Department Of Clinical Pharmacokinetics College Of Pharmacy Nihon University
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